Combination of phosphorylated and truncated EGFR correlates with higher tumor and nodal stage in head and neck cancer

James Keller; Kenneth R. Shroyer; Shishir K. Batajoo; Hong Ling Zhao; Li Ming Dong; Michael J. Hayman; Edward L. Chan

doi:10.3109/07357907.2010.512602

Combination of phosphorylated and truncated EGFR correlates with higher tumor and nodal stage in head and neck cancer

James Keller, Kenneth R. Shroyer, Shishir K. Batajoo, Hong Ling Zhao, Li Ming Dong, Michael J. Hayman, Edward L. Chan

Research output: Contribution to journal › Article › peer-review

19 Scopus citations

Abstract

Epidermal growth factor receptor (EGFR) is a target in head and neck cancer. High EGFR expression and phosphorylated EGFR predicts poor survival in head and neck cancer patients, but does not correlate with advanced stage disease. The aim of this study is to determine if clinical biological correlates are more accurate when different aspects of EGFR are evaluated in combination. We analyzed the EGFR phosphorylation, expression, and mutations in 60 primary head and neck tumors. We not only found that head and neck tumors with either truncated or activated EGFR tend to have higher tumor and nodal stage but also discovered two novel EGFR truncations.

Original language	English (US)
Pages (from-to)	1054-1062
Number of pages	9
Journal	Cancer Investigation
Volume	28
Issue number	10
DOIs	https://doi.org/10.3109/07357907.2010.512602
State	Published - Nov 2010
Externally published	Yes

Keywords

EGFRvIII
Head and neck squamous cell carcinomas
Phosphorylated EGFR
Truncated EGFR
Tyrosine kinase receptor

ASJC Scopus subject areas

Oncology
Cancer Research

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.3109/07357907.2010.512602

Cite this

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title = "Combination of phosphorylated and truncated EGFR correlates with higher tumor and nodal stage in head and neck cancer",

abstract = "Epidermal growth factor receptor (EGFR) is a target in head and neck cancer. High EGFR expression and phosphorylated EGFR predicts poor survival in head and neck cancer patients, but does not correlate with advanced stage disease. The aim of this study is to determine if clinical biological correlates are more accurate when different aspects of EGFR are evaluated in combination. We analyzed the EGFR phosphorylation, expression, and mutations in 60 primary head and neck tumors. We not only found that head and neck tumors with either truncated or activated EGFR tend to have higher tumor and nodal stage but also discovered two novel EGFR truncations.",

keywords = "EGFRvIII, Head and neck squamous cell carcinomas, Phosphorylated EGFR, Truncated EGFR, Tyrosine kinase receptor",

author = "James Keller and Shroyer, {Kenneth R.} and Batajoo, {Shishir K.} and Zhao, {Hong Ling} and Dong, {Li Ming} and Hayman, {Michael J.} and Chan, {Edward L.}",

year = "2010",

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language = "English (US)",

volume = "28",

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T1 - Combination of phosphorylated and truncated EGFR correlates with higher tumor and nodal stage in head and neck cancer

AU - Keller, James

AU - Shroyer, Kenneth R.

AU - Batajoo, Shishir K.

AU - Zhao, Hong Ling

AU - Dong, Li Ming

AU - Hayman, Michael J.

AU - Chan, Edward L.

PY - 2010/11

Y1 - 2010/11

N2 - Epidermal growth factor receptor (EGFR) is a target in head and neck cancer. High EGFR expression and phosphorylated EGFR predicts poor survival in head and neck cancer patients, but does not correlate with advanced stage disease. The aim of this study is to determine if clinical biological correlates are more accurate when different aspects of EGFR are evaluated in combination. We analyzed the EGFR phosphorylation, expression, and mutations in 60 primary head and neck tumors. We not only found that head and neck tumors with either truncated or activated EGFR tend to have higher tumor and nodal stage but also discovered two novel EGFR truncations.

AB - Epidermal growth factor receptor (EGFR) is a target in head and neck cancer. High EGFR expression and phosphorylated EGFR predicts poor survival in head and neck cancer patients, but does not correlate with advanced stage disease. The aim of this study is to determine if clinical biological correlates are more accurate when different aspects of EGFR are evaluated in combination. We analyzed the EGFR phosphorylation, expression, and mutations in 60 primary head and neck tumors. We not only found that head and neck tumors with either truncated or activated EGFR tend to have higher tumor and nodal stage but also discovered two novel EGFR truncations.

KW - EGFRvIII

KW - Head and neck squamous cell carcinomas

KW - Phosphorylated EGFR

KW - Truncated EGFR

KW - Tyrosine kinase receptor

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Combination of phosphorylated and truncated EGFR correlates with higher tumor and nodal stage in head and neck cancer

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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