TY - JOUR
T1 - Colony-stimulating factor-1 in immunity and inflammation
AU - Chitu, Violeta
AU - Stanley, E. Richard
N1 - Funding Information:
This work was supported by National Institutes of Health grants, CA32551, CA26504 and PO01 100324 (ERS), the Albert Einstein College of Medicine Cancer Center grant 5P30-CA13330 and a postdoctoral fellowship from the Susan G Komen Breast Cancer Foundation (PDF0201811) (VC). Please note that restrictions on the citation number have forced us to refer to reviews or individual papers in many areas.
PY - 2006/2
Y1 - 2006/2
N2 - Colony-stimulating factor-1 (CSF-1, also known as macrophage-CSF) is the primary regulator of the survival, proliferation, differentiation and function of mononuclear phagocytes. Studies that involve CSF-1-deficient mice demonstrate that there is a variable requirement for CSF-1 in the development of individual mononuclear phagocyte populations. However, these cells uniformly express the CSF-1 receptor, and their morphology, phagocytosis and responsiveness to infectious and non-infectious stimuli is regulated by CSF-1. CSF-1 plays important roles in innate immunity, cancer and inflammatory diseases, including systemic lupus erythematosus, arthritis, atherosclerosis and obesity. In several conditions, activation of macrophages involves a CSF-1 autocrine loop. In addition, secreted and cell-surface isoforms of CSF-1 can have differential effects in inflammation and immunity.
AB - Colony-stimulating factor-1 (CSF-1, also known as macrophage-CSF) is the primary regulator of the survival, proliferation, differentiation and function of mononuclear phagocytes. Studies that involve CSF-1-deficient mice demonstrate that there is a variable requirement for CSF-1 in the development of individual mononuclear phagocyte populations. However, these cells uniformly express the CSF-1 receptor, and their morphology, phagocytosis and responsiveness to infectious and non-infectious stimuli is regulated by CSF-1. CSF-1 plays important roles in innate immunity, cancer and inflammatory diseases, including systemic lupus erythematosus, arthritis, atherosclerosis and obesity. In several conditions, activation of macrophages involves a CSF-1 autocrine loop. In addition, secreted and cell-surface isoforms of CSF-1 can have differential effects in inflammation and immunity.
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U2 - 10.1016/j.coi.2005.11.006
DO - 10.1016/j.coi.2005.11.006
M3 - Review article
C2 - 16337366
AN - SCOPUS:30044448462
SN - 0952-7915
VL - 18
SP - 39
EP - 48
JO - Current Opinion in Immunology
JF - Current Opinion in Immunology
IS - 1
ER -
