Collecting-duct carcinoma of the kidney with prominent signet ring cell features

M. Li, M. A. Vuolo, K. M. Weidenheim, L. S. Minsky

Research output: Contribution to journalArticlepeer-review

17 Scopus citations


We report a case in a 74-year-old woman of collecting-duct carcinoma of the kidney with prominent signet ring cell features. Grossly, the tumor measured 5.5 cm in greatest dimension, occupied the entire upper pole of the kidney, and was well circumscribed. Microscopically, it displayed a predominant tubulopapillary pattern of growth with a hyalinizing stroma. The tumor tubules were lined by a single layer of cells with large, pleomorphic nuclei, some of which had a hobnail appearance. Large intracytoplasmic vacuoles with compression of nuclei (signet ring cells) were present throughout the tumor. Alcian blue, mucicarmine, and periodic acid-Schiff stains failed to identify intracellular mucin or glycogen in the signet ring cells. Enlarged cells with intracytoplasmic vacuoles were also noted in the adjacent collecting ducts. The tumor cells were immunohistochemically positive for cytokeratin including cytokeratin 7, CAM 5.2, AE1/3, and 34βE12, vimentin, peanut lectin agglutinin, and Ulex europaeus agglutinin. Electron microscopy revealed that the intracytoplasmic vacuoles were due to intracellular edema. To the best of our knowledge, this is the first reported case of renal collecting-duct carcinoma with prominent signet ring cell features.

Original languageEnglish (US)
Pages (from-to)623-628
Number of pages6
JournalModern Pathology
Issue number6
StatePublished - 2001


  • Collecting-duct carcinoma
  • Intracellular edema
  • Kidney
  • Signet ring cell

ASJC Scopus subject areas

  • General Medicine


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