Colchicine therapy of the renal amyloidosis of ulcerative colitis

Samuel Meyers, Henry D. Janowitz, Vivek V. Gumaste, Ruth G. Abramson, Laurence J. Berman, V. S. Venkataseshan, Steven H. Dickman

Research output: Contribution to journalArticlepeer-review

49 Scopus citations


Two patients with severe proteinuria, due to renal amyloidosis complicating chronic ulcerative colitis, improved remarkably with colchicine therapy. One patient with an initial daily urine protein excretion of 13.70 g had a reduction within 2 mo to 6.50 g and to 0.37 g after 9 yr. The other patient's daily urine protein excretion was 9.00 g. This was reduced to 5.10 g/day within 3 mo and was 0.53 g/day by 8 mo. Renal function remained stable or improved during the period of therapy. Colchicine resulted in rapid and prolonged benefit for these patients, despite their amyloid-induced nephrotic syndrome.

Original languageEnglish (US)
Pages (from-to)1503-1507
Number of pages5
Issue number6
StatePublished - Jun 1988
Externally publishedYes

ASJC Scopus subject areas

  • Hepatology
  • Gastroenterology


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