Colchicine therapy of the renal amyloidosis of ulcerative colitis

Samuel Meyers; Henry D. Janowitz; Vivek V. Gumaste; Ruth G. Abramson; Laurence J. Berman; V. S. Venkataseshan; Steven H. Dickman

doi:10.1016/0016-5085(88)90692-0

Colchicine therapy of the renal amyloidosis of ulcerative colitis

Samuel Meyers, Henry D. Janowitz, Vivek V. Gumaste, Ruth G. Abramson, Laurence J. Berman, V. S. Venkataseshan, Steven H. Dickman

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Abstract

Two patients with severe proteinuria, due to renal amyloidosis complicating chronic ulcerative colitis, improved remarkably with colchicine therapy. One patient with an initial daily urine protein excretion of 13.70 g had a reduction within 2 mo to 6.50 g and to 0.37 g after 9 yr. The other patient's daily urine protein excretion was 9.00 g. This was reduced to 5.10 g/day within 3 mo and was 0.53 g/day by 8 mo. Renal function remained stable or improved during the period of therapy. Colchicine resulted in rapid and prolonged benefit for these patients, despite their amyloid-induced nephrotic syndrome.

Original language	English (US)
Pages (from-to)	1503-1507
Number of pages	5
Journal	Gastroenterology
Volume	94
Issue number	6
DOIs	https://doi.org/10.1016/0016-5085(88)90692-0
State	Published - Jun 1988
Externally published	Yes

ASJC Scopus subject areas

Hepatology
Gastroenterology

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title = "Colchicine therapy of the renal amyloidosis of ulcerative colitis",

abstract = "Two patients with severe proteinuria, due to renal amyloidosis complicating chronic ulcerative colitis, improved remarkably with colchicine therapy. One patient with an initial daily urine protein excretion of 13.70 g had a reduction within 2 mo to 6.50 g and to 0.37 g after 9 yr. The other patient's daily urine protein excretion was 9.00 g. This was reduced to 5.10 g/day within 3 mo and was 0.53 g/day by 8 mo. Renal function remained stable or improved during the period of therapy. Colchicine resulted in rapid and prolonged benefit for these patients, despite their amyloid-induced nephrotic syndrome.",

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T1 - Colchicine therapy of the renal amyloidosis of ulcerative colitis

AU - Meyers, Samuel

AU - Janowitz, Henry D.

AU - Gumaste, Vivek V.

AU - Abramson, Ruth G.

AU - Berman, Laurence J.

AU - Venkataseshan, V. S.

AU - Dickman, Steven H.

PY - 1988/6

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N2 - Two patients with severe proteinuria, due to renal amyloidosis complicating chronic ulcerative colitis, improved remarkably with colchicine therapy. One patient with an initial daily urine protein excretion of 13.70 g had a reduction within 2 mo to 6.50 g and to 0.37 g after 9 yr. The other patient's daily urine protein excretion was 9.00 g. This was reduced to 5.10 g/day within 3 mo and was 0.53 g/day by 8 mo. Renal function remained stable or improved during the period of therapy. Colchicine resulted in rapid and prolonged benefit for these patients, despite their amyloid-induced nephrotic syndrome.

AB - Two patients with severe proteinuria, due to renal amyloidosis complicating chronic ulcerative colitis, improved remarkably with colchicine therapy. One patient with an initial daily urine protein excretion of 13.70 g had a reduction within 2 mo to 6.50 g and to 0.37 g after 9 yr. The other patient's daily urine protein excretion was 9.00 g. This was reduced to 5.10 g/day within 3 mo and was 0.53 g/day by 8 mo. Renal function remained stable or improved during the period of therapy. Colchicine resulted in rapid and prolonged benefit for these patients, despite their amyloid-induced nephrotic syndrome.

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Colchicine therapy of the renal amyloidosis of ulcerative colitis

Abstract

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