Cognitive dysfunction correlates with physical impairment in frail patients with acute myocardial infarction

Pasquale Mone, Jessica Gambardella, Antonella Pansini, Giuseppe Martinelli, Fabio Minicucci, Ciro Mauro, Gaetano Santulli

Research output: Contribution to journalArticlepeer-review

14 Scopus citations


Background: To the best of our knowledge, the association of physical impairment and cognitive decline has never been investigated in frail patients with acute myocardial infarction. Aim: The aim of our study is to assess the correlation between physical and cognitive dysfunction in frail patients with ST-elevation myocardial infarction (STEMI). Methods: We examined consecutive frail patients with first STEMI treated with primary percutaneous coronary intervention (PPCI). All patients were evaluated via Mini Mental State Examination (MMSE) and 5-m gait speed test after PPCI. Results: A total of 871 frail patients with suspected STEMI were admitted and 301 patients successfully completed the study. We found that the gait speed significantly correlated with the MMSE score (r: 0.771; p: < 0.001). The independent effects on MMSE score were confirmed in a linear multivariate analysis. Conclusions: Taken together, our findings indicate that an assessment of both cognitive and physical conditions should be included in the comprehensive geriatric evaluation of hospitalized older STEMI patients.

Original languageEnglish (US)
Pages (from-to)49-53
Number of pages5
JournalAging Clinical and Experimental Research
Issue number1
StatePublished - Jan 2022


  • Cognitive decline
  • Frailty
  • Gait speed test

ASJC Scopus subject areas

  • Aging
  • Geriatrics and Gerontology


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