Cognitive dysfunction correlates with physical impairment in frail patients with acute myocardial infarction

Pasquale Mone; Jessica Gambardella; Antonella Pansini; Giuseppe Martinelli; Fabio Minicucci; Ciro Mauro; Gaetano Santulli

doi:10.1007/s40520-021-01897-w

Cognitive dysfunction correlates with physical impairment in frail patients with acute myocardial infarction

Pasquale Mone, Jessica Gambardella, Antonella Pansini, Giuseppe Martinelli, Fabio Minicucci, Ciro Mauro, Gaetano Santulli

Medicine

Research output: Contribution to journal › Article › peer-review

25 Scopus citations

Abstract

Background: To the best of our knowledge, the association of physical impairment and cognitive decline has never been investigated in frail patients with acute myocardial infarction. Aim: The aim of our study is to assess the correlation between physical and cognitive dysfunction in frail patients with ST-elevation myocardial infarction (STEMI). Methods: We examined consecutive frail patients with first STEMI treated with primary percutaneous coronary intervention (PPCI). All patients were evaluated via Mini Mental State Examination (MMSE) and 5-m gait speed test after PPCI. Results: A total of 871 frail patients with suspected STEMI were admitted and 301 patients successfully completed the study. We found that the gait speed significantly correlated with the MMSE score (r: 0.771; p: < 0.001). The independent effects on MMSE score were confirmed in a linear multivariate analysis. Conclusions: Taken together, our findings indicate that an assessment of both cognitive and physical conditions should be included in the comprehensive geriatric evaluation of hospitalized older STEMI patients.

Original language	English (US)
Pages (from-to)	49-53
Number of pages	5
Journal	Aging Clinical and Experimental Research
Volume	34
Issue number	1
DOIs	https://doi.org/10.1007/s40520-021-01897-w
State	Published - Jan 2022

Keywords

Cognitive decline
Frailty
Gait speed test
STEMI

ASJC Scopus subject areas

Aging
Geriatrics and Gerontology

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title = "Cognitive dysfunction correlates with physical impairment in frail patients with acute myocardial infarction",

abstract = "Background: To the best of our knowledge, the association of physical impairment and cognitive decline has never been investigated in frail patients with acute myocardial infarction. Aim: The aim of our study is to assess the correlation between physical and cognitive dysfunction in frail patients with ST-elevation myocardial infarction (STEMI). Methods: We examined consecutive frail patients with first STEMI treated with primary percutaneous coronary intervention (PPCI). All patients were evaluated via Mini Mental State Examination (MMSE) and 5-m gait speed test after PPCI. Results: A total of 871 frail patients with suspected STEMI were admitted and 301 patients successfully completed the study. We found that the gait speed significantly correlated with the MMSE score (r: 0.771; p: < 0.001). The independent effects on MMSE score were confirmed in a linear multivariate analysis. Conclusions: Taken together, our findings indicate that an assessment of both cognitive and physical conditions should be included in the comprehensive geriatric evaluation of hospitalized older STEMI patients.",

keywords = "Cognitive decline, Frailty, Gait speed test, STEMI",

author = "Pasquale Mone and Jessica Gambardella and Antonella Pansini and Giuseppe Martinelli and Fabio Minicucci and Ciro Mauro and Gaetano Santulli",

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doi = "10.1007/s40520-021-01897-w",

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AU - Mone, Pasquale

AU - Gambardella, Jessica

AU - Pansini, Antonella

AU - Martinelli, Giuseppe

AU - Minicucci, Fabio

AU - Mauro, Ciro

AU - Santulli, Gaetano

PY - 2022/1

Y1 - 2022/1

N2 - Background: To the best of our knowledge, the association of physical impairment and cognitive decline has never been investigated in frail patients with acute myocardial infarction. Aim: The aim of our study is to assess the correlation between physical and cognitive dysfunction in frail patients with ST-elevation myocardial infarction (STEMI). Methods: We examined consecutive frail patients with first STEMI treated with primary percutaneous coronary intervention (PPCI). All patients were evaluated via Mini Mental State Examination (MMSE) and 5-m gait speed test after PPCI. Results: A total of 871 frail patients with suspected STEMI were admitted and 301 patients successfully completed the study. We found that the gait speed significantly correlated with the MMSE score (r: 0.771; p: < 0.001). The independent effects on MMSE score were confirmed in a linear multivariate analysis. Conclusions: Taken together, our findings indicate that an assessment of both cognitive and physical conditions should be included in the comprehensive geriatric evaluation of hospitalized older STEMI patients.

AB - Background: To the best of our knowledge, the association of physical impairment and cognitive decline has never been investigated in frail patients with acute myocardial infarction. Aim: The aim of our study is to assess the correlation between physical and cognitive dysfunction in frail patients with ST-elevation myocardial infarction (STEMI). Methods: We examined consecutive frail patients with first STEMI treated with primary percutaneous coronary intervention (PPCI). All patients were evaluated via Mini Mental State Examination (MMSE) and 5-m gait speed test after PPCI. Results: A total of 871 frail patients with suspected STEMI were admitted and 301 patients successfully completed the study. We found that the gait speed significantly correlated with the MMSE score (r: 0.771; p: < 0.001). The independent effects on MMSE score were confirmed in a linear multivariate analysis. Conclusions: Taken together, our findings indicate that an assessment of both cognitive and physical conditions should be included in the comprehensive geriatric evaluation of hospitalized older STEMI patients.

KW - Cognitive decline

KW - Frailty

KW - Gait speed test

KW - STEMI

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Cognitive dysfunction correlates with physical impairment in frail patients with acute myocardial infarction

Abstract

Keywords

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