Cognitive-behavioral therapy for patients with Parkinson's disease and comorbid major depressive disorder

Amy Farabaugh, Joseph J. Locascio, Liang Yap, John Growdon, Maurizio Fava, Christine Crawford, John Matthews, Jesse McCutchen, Jacqueline Buchin, Joel Pava, Jonathan E. Alpert

Research output: Contribution to journalArticlepeer-review

46 Scopus citations


Background: Depression has been recognized as a common feature of Parkinson's disease (PD), and is the most prevalent psychiatric disorder in PD patients. Objective: The authors sought to determine whether cognitive-behavioral therapy (CBT) is effective in the treatment of depression within the context of PD (dPD). Method: The authors enrolled 8 depressed PD patients into an open treatment study of 12 weeks of individual CBT treatment. Results: There was a significant linear decrease in mean Hamilton Rating Scale for Depression (17-item) scores over Weeks 0 to 12, and 57% of patients (4/7) met criteria for remission at endpoint. Conclusion: This uncontrolled study suggests that CBT may be effective in treating dPD and may be an alternative or adjunct to pharmacological treatment.

Original languageEnglish (US)
Pages (from-to)124-129
Number of pages6
Issue number2
StatePublished - Jan 1 2010
Externally publishedYes

ASJC Scopus subject areas

  • Arts and Humanities (miscellaneous)
  • Applied Psychology
  • Psychiatry and Mental health


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