Clinicopathologic investigation of a family with expanded SCA8 CTA/CTG repeats

H. Ito, H. Kawakami, R. Wate, S. Matsumoto, T. Imai, A. Hirano, H. Kusaka

Research output: Contribution to journalArticlepeer-review

32 Scopus citations


We investigated a family manifesting progressive ataxia, with expanded SCA8 CTA/CTG repeats. Neuropathologically, degeneration of Purkinje, inferior olivary, and nigral neurons and periaqueductal gliosis were evident. The sites of Purkinje cell loss were occupied by fibrillary accumulations. The remaining Purkinje cells showed somatic sprouts, and intracytoplasmic 1C2-positive granular structures were recognizable. This characteristic distribution of neurodegeneration and Purkinje cell cytopathology were distinct from those of other hereditary spinocerebellar ataxias previously reported.

Original languageEnglish (US)
Pages (from-to)1479-1481
Number of pages3
Issue number8
StatePublished - Oct 2006

ASJC Scopus subject areas

  • Clinical Neurology


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