TY - JOUR
T1 - Clinical relevance of cranial nerve injury following carotid endarterectomy
AU - Fokkema, M.
AU - De Borst, G. J.
AU - Nolan, B. W.
AU - Indes, J.
AU - Buck, D. B.
AU - Lo, R. C.
AU - Moll, F. L.
AU - Schermerhorn, M. L.
N1 - Funding Information:
This work was supported by the NIH T32 Harvard-Longwood Research Training in Vascular Surgery Grant HL007734 .
PY - 2014/1
Y1 - 2014/1
N2 - Objectives The benefit of carotid endarterectomy (CEA) may be diminished by cranial nerve injury (CNI). Using a quality improvement registry, we aimed to identify the nerves affected, duration of symptoms (transient vs. persistent), and clinical predictors of CNI. Methods We identified all patients undergoing CEA in the Vascular Study Group of New England (VSGNE) between 2003 and 2011. Surgeon-observed CNI rate was determined at discharge (postoperative CNI) and at follow-up to determine persistent CNI (CNIs that persisted at routine follow-up visit). Hierarchical multivariable model controlling for surgeon and hospital was used to assess independent predictors for postoperative CNI. Results A total of 6,878 patients (33.8% symptomatic) were included for analyses. CNI rate at discharge was 5.6% (n = 382). Sixty patients (0.7%) had more than one nerve affected. The hypoglossal nerve was most frequently involved (n = 185, 2.7%), followed by the facial (n = 128, 1.9%), the vagus (n = 49, 0.7%), and the glossopharyngeal (n = 33, 0.5%) nerve. The vast majority of these CNIs were transient; only 47 patients (0.7%) had a persistent CNI at their follow-up visit (median 10.0 months, range 0.3-15.6 months). Patients with perioperative stroke (0.9%, n = 64) had significantly higher risk of CNI (n = 15, CNI risk 23.4%, p <.01). Predictors for CNI were urgent procedures (OR 1.6, 95% CI 1.2-2.1, p <.01), immediate re-exploration after closure under the same anesthetic (OR 2.0, 95% CI 1.3-3.0, p <.01), and return to the operating room for a neurologic event or bleeding (OR 2.3, 95% CI 1.4-3.8, p <.01), but not redo CEA (OR 1.0, 95% CI 0.5-1.9, p =.90) or prior cervical radiation (OR 0.9, 95% CI 0.3-2.5, p =.80). Conclusions As patients are currently selected in the VSGNE, persistent CNI after CEA is rare. While conditions of urgency and (sub)acute reintervention carried increased risk for postoperative CNI, a history of prior ipsilateral CEA or cervical radiation was not associated with increased CNI rate.
AB - Objectives The benefit of carotid endarterectomy (CEA) may be diminished by cranial nerve injury (CNI). Using a quality improvement registry, we aimed to identify the nerves affected, duration of symptoms (transient vs. persistent), and clinical predictors of CNI. Methods We identified all patients undergoing CEA in the Vascular Study Group of New England (VSGNE) between 2003 and 2011. Surgeon-observed CNI rate was determined at discharge (postoperative CNI) and at follow-up to determine persistent CNI (CNIs that persisted at routine follow-up visit). Hierarchical multivariable model controlling for surgeon and hospital was used to assess independent predictors for postoperative CNI. Results A total of 6,878 patients (33.8% symptomatic) were included for analyses. CNI rate at discharge was 5.6% (n = 382). Sixty patients (0.7%) had more than one nerve affected. The hypoglossal nerve was most frequently involved (n = 185, 2.7%), followed by the facial (n = 128, 1.9%), the vagus (n = 49, 0.7%), and the glossopharyngeal (n = 33, 0.5%) nerve. The vast majority of these CNIs were transient; only 47 patients (0.7%) had a persistent CNI at their follow-up visit (median 10.0 months, range 0.3-15.6 months). Patients with perioperative stroke (0.9%, n = 64) had significantly higher risk of CNI (n = 15, CNI risk 23.4%, p <.01). Predictors for CNI were urgent procedures (OR 1.6, 95% CI 1.2-2.1, p <.01), immediate re-exploration after closure under the same anesthetic (OR 2.0, 95% CI 1.3-3.0, p <.01), and return to the operating room for a neurologic event or bleeding (OR 2.3, 95% CI 1.4-3.8, p <.01), but not redo CEA (OR 1.0, 95% CI 0.5-1.9, p =.90) or prior cervical radiation (OR 0.9, 95% CI 0.3-2.5, p =.80). Conclusions As patients are currently selected in the VSGNE, persistent CNI after CEA is rare. While conditions of urgency and (sub)acute reintervention carried increased risk for postoperative CNI, a history of prior ipsilateral CEA or cervical radiation was not associated with increased CNI rate.
KW - Carotid
KW - Cranial nerve injury
KW - Endarterectomy
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U2 - 10.1016/j.ejvs.2013.09.022
DO - 10.1016/j.ejvs.2013.09.022
M3 - Article
C2 - 24157257
AN - SCOPUS:84891945859
SN - 1078-5884
VL - 47
SP - 2
EP - 7
JO - European Journal of Vascular and Endovascular Surgery
JF - European Journal of Vascular and Endovascular Surgery
IS - 1
ER -