TY - JOUR
T1 - Clinical perspective - Cough
T2 - An unmet need
AU - Dicpinigaitis, Peter V.
N1 - Publisher Copyright:
© 2015 Elsevier Ltd. All rights reserved.
PY - 2015/6
Y1 - 2015/6
N2 - Cough is among the most common complaints for which individuals worldwide seek medical attention. The vast majority of cases of acute cough (<3 weeks duration) are due to acute viral upper respiratory tract infection (URI) (common cold). Fortunately, acute cough is typically transient and self-limited. However, should severe and/or persistent acute cough require pharmacological treatment, satisfactory therapeutic options are scarce. Narcotic antitussives are limited by unacceptable side effects at therapeutic doses, and most over-the-counter (OTC) remedies are not supported by adequate clinical trials. The goal in chronic cough (>8 weeks duration) is to meticulously evaluate and treat all potential underlying etiologies. Despite thorough investigation, a significant minority of patients will suffer refractory, unexplained cough. For this challenging population, safe, effective, non-narcotic antitussive therapies are desperately needed.
AB - Cough is among the most common complaints for which individuals worldwide seek medical attention. The vast majority of cases of acute cough (<3 weeks duration) are due to acute viral upper respiratory tract infection (URI) (common cold). Fortunately, acute cough is typically transient and self-limited. However, should severe and/or persistent acute cough require pharmacological treatment, satisfactory therapeutic options are scarce. Narcotic antitussives are limited by unacceptable side effects at therapeutic doses, and most over-the-counter (OTC) remedies are not supported by adequate clinical trials. The goal in chronic cough (>8 weeks duration) is to meticulously evaluate and treat all potential underlying etiologies. Despite thorough investigation, a significant minority of patients will suffer refractory, unexplained cough. For this challenging population, safe, effective, non-narcotic antitussive therapies are desperately needed.
UR - http://www.scopus.com/inward/record.url?scp=84924754751&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84924754751&partnerID=8YFLogxK
U2 - 10.1016/j.coph.2015.03.001
DO - 10.1016/j.coph.2015.03.001
M3 - Review article
C2 - 25771118
AN - SCOPUS:84924754751
SN - 1471-4892
VL - 22
SP - 24
EP - 28
JO - Current Opinion in Pharmacology
JF - Current Opinion in Pharmacology
M1 - 1400
ER -