TY - JOUR
T1 - Clinical case analysis of 32 children aged 0–6 years with lead poisoning in Nanning, China
AU - Wei, Yi Fei
AU - Gan, Cui Liu
AU - Xu, Fang
AU - Fang, Yuan Yuan
AU - Zhang, Bao Dan
AU - Li, Wu Shu
AU - Nong, Kang
AU - Michael, Aschner
AU - Jiang, Yue Ming
N1 - Publisher Copyright:
© The Author(s) 2023.
PY - 2024/1/1
Y1 - 2024/1/1
N2 - Lead is one of the heavy metals that is toxic and widely distributed in the environment, and children are more sensitive to the toxic effects of lead because the blood–brain barrier and immune system are not yet well developed. The objective of the study was to investigate the clinical characteristics of lead poisoning in children aged 0∼6 years in a hospital in Guangxi, and to provide scientific basis for the prevention and treatment of lead poisoning. We collected and analyzed the clinical data of 32 children with lead poisoning admitted to a hospital in Guangxi from 2010 to 2018. The results showed that most of the 32 cases presented with hyperactivity, irritability, poor appetite, abdominal pain, diarrhea, or constipation. The hemoglobin (HGB), mean corpusular volume (MCV), mean corpuscular hemoglobin (MCH), and hematocrit (HCT) of the lead-poisoned children were all decreased to different degrees and were below normal acceptable levels. Urinary β2-microglobulin was increased. Blood lead levels (BLL) decreased significantly after intravenous injection of the lead chelator, calcium disodium edetate (CaNa2-EDTA). In addition, HGB returned to normal levels, while MCV, MCH, and HCT increased but remained below normal levels. Urinary β2-microglobulin was reduced to normal levels. Therefore, in this cohort of children, the high-risk factors for lead poisoning are mainly Chinese medicines, such as baby powder. In conclusion, lead poisoning caused neurological damage and behavioral changes in children and decreased erythrocyte parameters, leading to digestive symptoms and renal impairment, which can be attenuated by CaNa2-EDTA treatment.
AB - Lead is one of the heavy metals that is toxic and widely distributed in the environment, and children are more sensitive to the toxic effects of lead because the blood–brain barrier and immune system are not yet well developed. The objective of the study was to investigate the clinical characteristics of lead poisoning in children aged 0∼6 years in a hospital in Guangxi, and to provide scientific basis for the prevention and treatment of lead poisoning. We collected and analyzed the clinical data of 32 children with lead poisoning admitted to a hospital in Guangxi from 2010 to 2018. The results showed that most of the 32 cases presented with hyperactivity, irritability, poor appetite, abdominal pain, diarrhea, or constipation. The hemoglobin (HGB), mean corpusular volume (MCV), mean corpuscular hemoglobin (MCH), and hematocrit (HCT) of the lead-poisoned children were all decreased to different degrees and were below normal acceptable levels. Urinary β2-microglobulin was increased. Blood lead levels (BLL) decreased significantly after intravenous injection of the lead chelator, calcium disodium edetate (CaNa2-EDTA). In addition, HGB returned to normal levels, while MCV, MCH, and HCT increased but remained below normal levels. Urinary β2-microglobulin was reduced to normal levels. Therefore, in this cohort of children, the high-risk factors for lead poisoning are mainly Chinese medicines, such as baby powder. In conclusion, lead poisoning caused neurological damage and behavioral changes in children and decreased erythrocyte parameters, leading to digestive symptoms and renal impairment, which can be attenuated by CaNa2-EDTA treatment.
KW - CaNa-EDTA
KW - Lead poisoning
KW - children
KW - erythrocyte parameters
KW - neurotoxicity
KW - urinary β-microglobulin
UR - http://www.scopus.com/inward/record.url?scp=85177455390&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85177455390&partnerID=8YFLogxK
U2 - 10.1177/07482337231215411
DO - 10.1177/07482337231215411
M3 - Article
AN - SCOPUS:85177455390
SN - 0748-2337
VL - 40
SP - 41
EP - 51
JO - Toxicology and Industrial Health
JF - Toxicology and Industrial Health
IS - 1-2
ER -
