TY - JOUR
T1 - Circulating antioxidant defences are decreased in healthy people after a high-fat meal
AU - Cardona, Fernando
AU - Túnez, Isaac
AU - Tasset, Inmaculada
AU - Garrido-Sánchez, Lourdes
AU - Collantes, Eduardo
AU - Tinahones, Francisco José
PY - 2008
Y1 - 2008
N2 - The aim of this study was to examine the responses of uric acid, antioxidant defences and pro-oxidant variables after a high-fat meal. Twenty-five healthy persons without criteria for the metabolic syndrome, underwent a high-fat meal with Supracal® (60 g fat). Measurements were made at baseline and 3 h after the meal of TAG, uric acid, HDL-cholesterol, total proteins and oxidative stress. Following the high-fat meal, we detected a significant increase in pro-oxidative variables and a decrease in antioxidative variables. The uric acid concentrations were significantly lower after the high-fat meal and the reduction correlated significantly with the oxidative stress variables. The inverse relation between reduced uric acid and increased carbonylated proteins remained in multiple regression analysis. We conclude that uric acid is a powerful antioxidant and its reduction following a high-fat meal may be related with its acute antioxidative action.
AB - The aim of this study was to examine the responses of uric acid, antioxidant defences and pro-oxidant variables after a high-fat meal. Twenty-five healthy persons without criteria for the metabolic syndrome, underwent a high-fat meal with Supracal® (60 g fat). Measurements were made at baseline and 3 h after the meal of TAG, uric acid, HDL-cholesterol, total proteins and oxidative stress. Following the high-fat meal, we detected a significant increase in pro-oxidative variables and a decrease in antioxidative variables. The uric acid concentrations were significantly lower after the high-fat meal and the reduction correlated significantly with the oxidative stress variables. The inverse relation between reduced uric acid and increased carbonylated proteins remained in multiple regression analysis. We conclude that uric acid is a powerful antioxidant and its reduction following a high-fat meal may be related with its acute antioxidative action.
KW - High-fat meal
KW - Oxidative stress
KW - Postprandial hyperlipidaemia
KW - Uric acid
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U2 - 10.1017/S0007114507894347
DO - 10.1017/S0007114507894347
M3 - Article
C2 - 18184452
AN - SCOPUS:52949103718
SN - 0007-1145
VL - 100
SP - 312
EP - 316
JO - British Journal of Nutrition
JF - British Journal of Nutrition
IS - 2
ER -