Circular RNAs: pivotal role in the leukemogenesis and novel indicators for the diagnosis and prognosis of acute myeloid leukemia

Atefe Rahmati; Alireza Mafi; Firooze Soleymani; Zahra Babaei Aghdam; Niloufar Masihipour; Behrooz Ghezelbash; Reza Asemi; Michael Aschner; Omid Vakili; Mina Homayoonfal; Zatollah Asemi; Mehran Sharifi; Abbas Azadi; Hamed Mirzaei; Esmat Aghadavod

doi:10.3389/fonc.2023.1149187

Circular RNAs: pivotal role in the leukemogenesis and novel indicators for the diagnosis and prognosis of acute myeloid leukemia

Atefe Rahmati, Alireza Mafi, Firooze Soleymani, Zahra Babaei Aghdam, Niloufar Masihipour, Behrooz Ghezelbash, Reza Asemi, Michael Aschner, Omid Vakili, Mina Homayoonfal, Zatollah Asemi, Mehran Sharifi, Abbas Azadi, Hamed Mirzaei, Esmat Aghadavod

Molecular Pharmacology

Research output: Contribution to journal › Review article › peer-review

4 Scopus citations

Abstract

Acute myeloid leukemia (AML) is an aggressive hematological malignancy and affected patients have poor overall survival (OS) rates. Circular RNAs (circRNAs) are a novel class of non-coding RNAs (ncRNAs) with a unique loop structure. In recent years, with the development of high-throughput RNA sequencing, many circRNAs have been identified exhibiting either up-regulation or down-regulation in AML patients compared with healthy controls. Recent studies have reported that circRNAs regulate leukemia cell proliferation, stemness, and apoptosis, both positively and negatively. Additionally, circRNAs could be promising biomarkers and therapeutic targets in AML. In this study, we present a comprehensive review of the regulatory roles and potentials of a number of dysregulated circRNAs in AML.

Original language	English (US)
Article number	1149187
Journal	Frontiers in Oncology
Volume	13
DOIs	https://doi.org/10.3389/fonc.2023.1149187
State	Published - 2023

Keywords

acute myeloid leukemia
biomarker
circular RNA (circRNA)
microRNA
targeted therapy

ASJC Scopus subject areas

Oncology
Cancer Research

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.3389/fonc.2023.1149187

Cite this

Rahmati, A., Mafi, A., Soleymani, F., Babaei Aghdam, Z., Masihipour, N., Ghezelbash, B., Asemi, R., Aschner, M., Vakili, O., Homayoonfal, M., Asemi, Z., Sharifi, M., Azadi, A., Mirzaei, H., & Aghadavod, E. (2023). Circular RNAs: pivotal role in the leukemogenesis and novel indicators for the diagnosis and prognosis of acute myeloid leukemia. Frontiers in Oncology, 13, Article 1149187. https://doi.org/10.3389/fonc.2023.1149187

Rahmati, A, Mafi, A, Soleymani, F, Babaei Aghdam, Z, Masihipour, N, Ghezelbash, B, Asemi, R, Aschner, M, Vakili, O, Homayoonfal, M, Asemi, Z, Sharifi, M, Azadi, A, Mirzaei, H & Aghadavod, E 2023, 'Circular RNAs: pivotal role in the leukemogenesis and novel indicators for the diagnosis and prognosis of acute myeloid leukemia', Frontiers in Oncology, vol. 13, 1149187. https://doi.org/10.3389/fonc.2023.1149187

@article{fb92e36df5024de7a485a834cfe4be24,

title = "Circular RNAs: pivotal role in the leukemogenesis and novel indicators for the diagnosis and prognosis of acute myeloid leukemia",

abstract = "Acute myeloid leukemia (AML) is an aggressive hematological malignancy and affected patients have poor overall survival (OS) rates. Circular RNAs (circRNAs) are a novel class of non-coding RNAs (ncRNAs) with a unique loop structure. In recent years, with the development of high-throughput RNA sequencing, many circRNAs have been identified exhibiting either up-regulation or down-regulation in AML patients compared with healthy controls. Recent studies have reported that circRNAs regulate leukemia cell proliferation, stemness, and apoptosis, both positively and negatively. Additionally, circRNAs could be promising biomarkers and therapeutic targets in AML. In this study, we present a comprehensive review of the regulatory roles and potentials of a number of dysregulated circRNAs in AML.",

keywords = "acute myeloid leukemia, biomarker, circular RNA (circRNA), microRNA, targeted therapy",

author = "Atefe Rahmati and Alireza Mafi and Firooze Soleymani and {Babaei Aghdam}, Zahra and Niloufar Masihipour and Behrooz Ghezelbash and Reza Asemi and Michael Aschner and Omid Vakili and Mina Homayoonfal and Zatollah Asemi and Mehran Sharifi and Abbas Azadi and Hamed Mirzaei and Esmat Aghadavod",

note = "Publisher Copyright: Copyright {\textcopyright} 2023 Rahmati, Mafi, Soleymani, Babaei Aghdam, Masihipour, Ghezelbash, Asemi, Aschner, Vakili, Homayoonfal, Asemi, Sharifi, Azadi, Mirzaei and Aghadavod.",

year = "2023",

doi = "10.3389/fonc.2023.1149187",

language = "English (US)",

volume = "13",

journal = "Frontiers in Oncology",

issn = "2234-943X",

publisher = "Frontiers Media S. A.",

}

TY - JOUR

T1 - Circular RNAs

T2 - pivotal role in the leukemogenesis and novel indicators for the diagnosis and prognosis of acute myeloid leukemia

AU - Rahmati, Atefe

AU - Mafi, Alireza

AU - Soleymani, Firooze

AU - Babaei Aghdam, Zahra

AU - Masihipour, Niloufar

AU - Ghezelbash, Behrooz

AU - Asemi, Reza

AU - Aschner, Michael

AU - Vakili, Omid

AU - Homayoonfal, Mina

AU - Asemi, Zatollah

AU - Sharifi, Mehran

AU - Azadi, Abbas

AU - Mirzaei, Hamed

AU - Aghadavod, Esmat

PY - 2023

Y1 - 2023

N2 - Acute myeloid leukemia (AML) is an aggressive hematological malignancy and affected patients have poor overall survival (OS) rates. Circular RNAs (circRNAs) are a novel class of non-coding RNAs (ncRNAs) with a unique loop structure. In recent years, with the development of high-throughput RNA sequencing, many circRNAs have been identified exhibiting either up-regulation or down-regulation in AML patients compared with healthy controls. Recent studies have reported that circRNAs regulate leukemia cell proliferation, stemness, and apoptosis, both positively and negatively. Additionally, circRNAs could be promising biomarkers and therapeutic targets in AML. In this study, we present a comprehensive review of the regulatory roles and potentials of a number of dysregulated circRNAs in AML.

AB - Acute myeloid leukemia (AML) is an aggressive hematological malignancy and affected patients have poor overall survival (OS) rates. Circular RNAs (circRNAs) are a novel class of non-coding RNAs (ncRNAs) with a unique loop structure. In recent years, with the development of high-throughput RNA sequencing, many circRNAs have been identified exhibiting either up-regulation or down-regulation in AML patients compared with healthy controls. Recent studies have reported that circRNAs regulate leukemia cell proliferation, stemness, and apoptosis, both positively and negatively. Additionally, circRNAs could be promising biomarkers and therapeutic targets in AML. In this study, we present a comprehensive review of the regulatory roles and potentials of a number of dysregulated circRNAs in AML.

KW - acute myeloid leukemia

KW - biomarker

KW - circular RNA (circRNA)

KW - microRNA

KW - targeted therapy

UR - http://www.scopus.com/inward/record.url?scp=85159799482&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85159799482&partnerID=8YFLogxK

U2 - 10.3389/fonc.2023.1149187

DO - 10.3389/fonc.2023.1149187

M3 - Review article

AN - SCOPUS:85159799482

SN - 2234-943X

VL - 13

JO - Frontiers in Oncology

JF - Frontiers in Oncology

M1 - 1149187

ER -

Circular RNAs: pivotal role in the leukemogenesis and novel indicators for the diagnosis and prognosis of acute myeloid leukemia

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

Access to Document

Other files and links

Fingerprint

Cite this