TY - JOUR
T1 - Cigarette smoking is an independent predictor of nonadherence in HIV-infected individuals receiving highly active antiretroviral therapy
AU - Shuter, Jonathan
AU - Bernstein, Steven
PY - 2008/4
Y1 - 2008/4
N2 - Current treatment guidelines for the management of HIV-infected individuals emphasize the importance of excellent adherence to antiretroviral medications. We conducted a prospective 24-week study of adherence to lopinavir/ritonavir in a group of 64 subjects using the Medication Event Monitoring System (MEMS). A range of demographic and clinical information, including cigarette smoking status, was collected from each participant. The overall mean adherence rate of the study cohort was 72.8% (SD=22.2%). Current smokers took 63.5% (SD=22.1) of prescribed doses, compared with 84.8% (SD=15.8%) in nonsmokers (p<.001). We found no difference in adherence rates between ex-smokers and subjects who had never smoked. In a multiple linear regression model, factors independently associated with lower adherence rates included current smoking (p=.001), lower CD4+ lymphocyte count at enrollment (p=.04), and lower educational attainment (p=.04). Depression and history of illicit substance use were not associated with nonadherence. In our study cohort, current cigarette smoking was an important and significant marker of inferior adherence to antiretroviral medication.
AB - Current treatment guidelines for the management of HIV-infected individuals emphasize the importance of excellent adherence to antiretroviral medications. We conducted a prospective 24-week study of adherence to lopinavir/ritonavir in a group of 64 subjects using the Medication Event Monitoring System (MEMS). A range of demographic and clinical information, including cigarette smoking status, was collected from each participant. The overall mean adherence rate of the study cohort was 72.8% (SD=22.2%). Current smokers took 63.5% (SD=22.1) of prescribed doses, compared with 84.8% (SD=15.8%) in nonsmokers (p<.001). We found no difference in adherence rates between ex-smokers and subjects who had never smoked. In a multiple linear regression model, factors independently associated with lower adherence rates included current smoking (p=.001), lower CD4+ lymphocyte count at enrollment (p=.04), and lower educational attainment (p=.04). Depression and history of illicit substance use were not associated with nonadherence. In our study cohort, current cigarette smoking was an important and significant marker of inferior adherence to antiretroviral medication.
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U2 - 10.1080/14622200801908190
DO - 10.1080/14622200801908190
M3 - Article
C2 - 18418794
AN - SCOPUS:42449156793
SN - 1462-2203
VL - 10
SP - 731
EP - 736
JO - Nicotine and Tobacco Research
JF - Nicotine and Tobacco Research
IS - 4
ER -