Chrysin Effect Against Gastric Cancer: Focus on its Molecular Mechanisms

Seyyed Mohammad Matin Alavi Dana; Tahereh Farkhondeh; Michael Aschner; Majid Darroudi; Helia Samini; Saeed Samarghandian

doi:10.2174/1874467216666230103105725

Chrysin Effect Against Gastric Cancer: Focus on its Molecular Mechanisms

Seyyed Mohammad Matin Alavi Dana, Tahereh Farkhondeh, Michael Aschner, Majid Darroudi, Helia Samini, Saeed Samarghandian

Molecular Pharmacology

Research output: Contribution to journal › Review article › peer-review

1 Scopus citations

Abstract

Gastric cancer is one of the most prevalent cancers in the world. Various therapeutic modalities have been used for its treatment, but all exhibit severe side effects, establishing the need for novel approaches. Chrysin is a phytomedicine compound belonging to the flavonoid group. It is found in honey and many plants. Its antitumor effects have been documented against gastric cancer cell lines in vitro, establishing its effects are mediated via different pathways and the expression of miRNA. In this review, we summarize the available literature on chrysin and its effects on gastric cancer, focusing on the cellular mechanisms it targets.

Original language	English (US)
Pages (from-to)	707-711
Number of pages	5
Journal	Current Molecular Pharmacology
Volume	16
Issue number	7
DOIs	https://doi.org/10.2174/1874467216666230103105725
State	Published - 2023

Keywords

5,7-dihydroxy-flavone
Chrysin
gastric cancer
mechanisms of action
molecular mechanisms
signaling pathway

ASJC Scopus subject areas

Molecular Medicine
Pharmacology
Drug Discovery

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.2174/1874467216666230103105725

Cite this

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title = "Chrysin Effect Against Gastric Cancer: Focus on its Molecular Mechanisms",

abstract = "Gastric cancer is one of the most prevalent cancers in the world. Various therapeutic modalities have been used for its treatment, but all exhibit severe side effects, establishing the need for novel approaches. Chrysin is a phytomedicine compound belonging to the flavonoid group. It is found in honey and many plants. Its antitumor effects have been documented against gastric cancer cell lines in vitro, establishing its effects are mediated via different pathways and the expression of miRNA. In this review, we summarize the available literature on chrysin and its effects on gastric cancer, focusing on the cellular mechanisms it targets.",

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T2 - Focus on its Molecular Mechanisms

AU - Alavi Dana, Seyyed Mohammad Matin

AU - Farkhondeh, Tahereh

AU - Aschner, Michael

AU - Darroudi, Majid

AU - Samini, Helia

AU - Samarghandian, Saeed

PY - 2023

Y1 - 2023

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AB - Gastric cancer is one of the most prevalent cancers in the world. Various therapeutic modalities have been used for its treatment, but all exhibit severe side effects, establishing the need for novel approaches. Chrysin is a phytomedicine compound belonging to the flavonoid group. It is found in honey and many plants. Its antitumor effects have been documented against gastric cancer cell lines in vitro, establishing its effects are mediated via different pathways and the expression of miRNA. In this review, we summarize the available literature on chrysin and its effects on gastric cancer, focusing on the cellular mechanisms it targets.

KW - 5,7-dihydroxy-flavone

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KW - gastric cancer

KW - mechanisms of action

KW - molecular mechanisms

KW - signaling pathway

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Chrysin Effect Against Gastric Cancer: Focus on its Molecular Mechanisms

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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