Chronic lyme arthritis. Clinical and immunogenetic differentiation from rheumatoid arthritis

A. C. Steere, A. Gibofsky, M. E. Patarroyo, R. J. Winchester, J. A. Hardin, S. E. Malawista

Research output: Contribution to journalArticlepeer-review

187 Scopus citations


Ten patients with Lyme arthritis have developed chronic involvement of one or both knees. Lyme arthritis was diagnosed by onset with erythema chronicum migrans (six patients); residence in Lyme, Connecticut (eight); seasonal onset in summer and early fall (nine); early periods of short recurrent attacks (nine); absence of rheumatoid factor (nine); and absence of symmetrical polyarthritis, morning stiffness, subcutaneous nodules, or antinuclear antibodies (in all). Five patients had synovectomies; pannus formation and underlying cartilage erosion were present in all. Seven of the 10 patients had the same B-cell alloantigen, DRw2 (frequency in normal control subjects, 22% [P<0.005]), but did not have an increased frequency of the alloantigens associated with rheumatoid arthritis. Chronic Lyme arthritis, the result of an apparent tick-transmitted infection, resembles rheumatoid arthritis pathologically but generally differs from it in both prearticular and immunogenetic characteristics.

Original languageEnglish (US)
Pages (from-to)896-901
Number of pages6
JournalUnknown Journal
Issue number6
StatePublished - Jan 1 1979

ASJC Scopus subject areas

  • Internal Medicine


Dive into the research topics of 'Chronic lyme arthritis. Clinical and immunogenetic differentiation from rheumatoid arthritis'. Together they form a unique fingerprint.

Cite this