Chronic kidney disease: A life course health development perspective

Patrick D. Brophy, Jennifer R. Charlton, J. Bryan Carmody, Kimberly J. Reidy, Lyndsay Harshman, Jeffrey Segar, David Askenazi, David Shoham, Susan P. Bagby

Research output: Chapter in Book/Report/Conference proceedingChapter

10 Scopus citations


Chronic kidney disease (CKD) reflects life events that range from maternal-fetal influences to geriatric exposures. The global direct and indirect costs of CKD are high and include maternal-neonatal hospitalization and treatment, acute kidney injury, dialysis and transplant, missed work, and medications, to name a few. The impact of poor diet, adverse childhood experiences, medication use, and failure to follow consistent public health standards are increasingly appreciated as key influences in the development of CKD. Socioeconomic factors can significantly influence the timing and phenotypic expression in people at risk for developing CKD, although more research is needed to understand these mechanisms. In general, biomedicine has been focused on treating well-established CKD morbidity. This strategy has been short sighted and costly. A more cost-effective approach would focus on early life interventions that hold the potential for mitigating CKD risk and its sequelae. This chapter applies the life course health development principles to review determinants and pathways for CKD evolution and identifies of the gaps in our knowledgebase. We also discuss several research strategies for evaluating the life course health development of CKD.

Original languageEnglish (US)
Title of host publicationHandbook of Life Course Health Development
PublisherSpringer International Publishing
Number of pages27
ISBN (Electronic)9783319471433
ISBN (Print)9783319471419
StatePublished - Jan 1 2017

ASJC Scopus subject areas

  • Psychology(all)
  • Social Sciences(all)
  • Economics, Econometrics and Finance(all)
  • Business, Management and Accounting(all)
  • Medicine(all)


Dive into the research topics of 'Chronic kidney disease: A life course health development perspective'. Together they form a unique fingerprint.

Cite this