TY - JOUR
T1 - Chromosome localization of human ARH genes, a ras-related gene family
AU - Cannizzaro, Linda A.
AU - Madaule, Pascal
AU - Hecht, Frederick
AU - Axel, Richard
AU - Croce, Carlo M.
AU - Huebner, Kay
N1 - Funding Information:
We thank Michael J. Mendez, Wendy Scattergood, Angert for skillful technical assistance and Axe1 Ullrich, lenberg, Peter Ralph, and Judy Abraham for generously us with chromosome 5 markers. This work was supported Grants CA-41124 (F.H.), CA-21124, CA-25875, CA-39860, 405 (L.A.C.) from the American Cancer Society.
PY - 1990/2
Y1 - 1990/2
N2 - The human ARH genes (previously called RHO) share several properties with the ras gene family. Three members of the ARH family, the H6, H9, and H12 genes, have been localized to human chromosomes 2, 5, and 3, respectively. Analysis of DNAs from a rodent-human somatic cell hybrid panel demonstrates linkage of H6 to chromosome region 2p12→2pter and H9 to region 5q33→5qter. In situ chromosome hybridization also showed that the primary site for H9 is in the 5q31→-qter region. The H12 gene was some-what difficult to localize using rodent-human hybrids because the probe detects a family of rodent genes as homologous to the human probe as is the human cognate gene. However, chromosome in situ hybridization revealed grains clustered in region 3p14→3p22 with a significant peak in band 3p21. We conclude that H6 is in 2p12→pter, H9 in 5q31→5qter, and H12 in 3p21.
AB - The human ARH genes (previously called RHO) share several properties with the ras gene family. Three members of the ARH family, the H6, H9, and H12 genes, have been localized to human chromosomes 2, 5, and 3, respectively. Analysis of DNAs from a rodent-human somatic cell hybrid panel demonstrates linkage of H6 to chromosome region 2p12→2pter and H9 to region 5q33→5qter. In situ chromosome hybridization also showed that the primary site for H9 is in the 5q31→-qter region. The H12 gene was some-what difficult to localize using rodent-human hybrids because the probe detects a family of rodent genes as homologous to the human probe as is the human cognate gene. However, chromosome in situ hybridization revealed grains clustered in region 3p14→3p22 with a significant peak in band 3p21. We conclude that H6 is in 2p12→pter, H9 in 5q31→5qter, and H12 in 3p21.
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U2 - 10.1016/0888-7543(90)90557-B
DO - 10.1016/0888-7543(90)90557-B
M3 - Article
C2 - 2407642
AN - SCOPUS:0025347284
SN - 0888-7543
VL - 6
SP - 197
EP - 203
JO - Genomics
JF - Genomics
IS - 2
ER -