@article{f2151db0538444279ed6c566c7c1e9c2,
title = "Chromatin modifications, epigenetics, and how protozoan parasites regulate their lives",
abstract = "Chromatin structure plays a vital role in epigenetic regulation of protozoan parasite gene expression. Epigenetic gene regulation impacts upon parasite virulence, differentiation and cell-cycle control. Recent work in many laboratories has elucidated the functions of proteins that regulate parasite gene expression by chemical modification of constituent nucleosomes. A major focus of investigation has been the characterization of post-translational modifications (PTMs) of histones and the identification of the enzymes responsible. Despite conserved features and specificity common to all eukaryotes, parasite enzymes involved in chromatin modification have unique functions that regulate unique aspects of parasite biology.",
author = "Croken, {Matthew M.} and Nardelli, {Sheila C.} and Kami Kim",
note = "Funding Information: We thank William Sullivan for critical review of the manuscript. M.M.C. was supported by the Training Program in Cellular and Molecular Biology and Genetics, funded by National Institutes of Health (NIH) grant T32 GM007491 awarded to the Albert Einstein College of Medicine. Some of this work will be published in a thesis submitted in partial fulfillment of the requirements for a Doctor of Philosophy conferred by the Sue Golding Graduate Division of the Albert Einstein College of Medicine (M.M.C.). S.C.N. was supported by NIH Fogarty Geographic Infectious Diseases Training Grant D43TW007129. This work was partially supported by NIH grants R01 AI087625, RC4 AI092801 (to K.K.) and the Einstein-Montefiore Center for AIDS Research, funded by P30AI051519. ",
year = "2012",
month = may,
doi = "10.1016/j.pt.2012.02.009",
language = "English (US)",
volume = "28",
pages = "202--213",
journal = "Trends in Parasitology",
issn = "1471-4922",
publisher = "Elsevier Limited",
number = "5",
}
