Chondroitin sulphate and peritoneal permeability.

A. Breborowicz, K. Wieczorowska, J. Knapowski, L. Martis, K. D. Serkes, D. G. Oreopoulos

Research output: Contribution to journalArticlepeer-review

2 Scopus citations


We studied the effect of chronic intraperitoneal (ip) infusion of saline supplemented with the glycosaminoglycan-chondroitin sulphate 0.1% on the permeability and peroxidation of the peritoneal membrane in rats and compared this with the effect of saline infusion alone. Animals treated with chondroitin sulphate had a higher net ultrafiltration (uf), a slower glucose absorption from the dialysate and less trans-peritoneal loss of proteins. Chronic ip infusion of chondroitin sulphate reduced peroxidation of the peritoneum. These observations suggest that chondroitin may effect the peritoneal interstitium-an important barrier of fluid and solutes transport.

Original languageEnglish (US)
Pages (from-to)11-14
Number of pages4
JournalAdvances in peritoneal dialysis. Conference on Peritoneal Dialysis
StatePublished - 1992

ASJC Scopus subject areas

  • General Medicine


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