Chlorozotocin: Phase II evaluation in patients with advanced sarcomas

P. P. Sordillo, G. B. Magill, R. J. Gralla

Research output: Contribution to journalArticlepeer-review

4 Scopus citations


Chlorozotocin is a water-soluble nitrosourea with high alkylating and low carbamoylating activities; it has demonstrated activity in several animal tumor systems including B16 melanoma and L1210 leukemia. Occasional responses have been noted in patients with lymphoma, Hodgkin's disease, melanoma, and carcinomas of the colon, breast, and ovary. Published phase II studies of chlorozotocin used against carcinomas of the lung and kidney have shown minimal activity. A phase II trial of this agent was undertaken to assess its activity against soft tissue sarcomas.

Original languageEnglish (US)
Pages (from-to)513-514
Number of pages2
JournalCancer Treatment Reports
Issue number5-6
StatePublished - 1981
Externally publishedYes

ASJC Scopus subject areas

  • Oncology
  • Cancer Research


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