Chemosterilant action of anthramycin: A proposed mechanism

Susan B. Horwitz; Shen Chin Chang; Arthur P. Grollman; Alexej B. Bořkovec

doi:10.1126/science.174.4005.159

Chemosterilant action of anthramycin: A proposed mechanism

Susan B. Horwitz, Shen Chin Chang, Arthur P. Grollman, Alexej B. Bořkovec

Molecular Pharmacology

Research output: Contribution to journal › Article › peer-review

22 Scopus citations

Abstract

The activity of anthramycin and structurally related analogs as chemosterilants of the housefly, Musca domestica L., correlates closely with the action of these compounds as inhibitors of Escherichia coli RNA polymerase. Since inhibition of RNA polymerase by anthramycin reflects binding of this antibiotic to the DNA primer required for enzyme activity, we propose that the interaction of anthramycin with DNA may also account for its action as a chemosterilant.

Original language	English (US)
Pages (from-to)	159-161
Number of pages	3
Journal	Science
Volume	174
Issue number	4005
DOIs	https://doi.org/10.1126/science.174.4005.159
State	Published - 1971

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title = "Chemosterilant action of anthramycin: A proposed mechanism",

abstract = "The activity of anthramycin and structurally related analogs as chemosterilants of the housefly, Musca domestica L., correlates closely with the action of these compounds as inhibitors of Escherichia coli RNA polymerase. Since inhibition of RNA polymerase by anthramycin reflects binding of this antibiotic to the DNA primer required for enzyme activity, we propose that the interaction of anthramycin with DNA may also account for its action as a chemosterilant.",

author = "Horwitz, {Susan B.} and Chang, {Shen Chin} and Grollman, {Arthur P.} and Bo{\v r}kovec, {Alexej B.}",

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AU - Chang, Shen Chin

AU - Grollman, Arthur P.

AU - Bořkovec, Alexej B.

PY - 1971

Y1 - 1971

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AB - The activity of anthramycin and structurally related analogs as chemosterilants of the housefly, Musca domestica L., correlates closely with the action of these compounds as inhibitors of Escherichia coli RNA polymerase. Since inhibition of RNA polymerase by anthramycin reflects binding of this antibiotic to the DNA primer required for enzyme activity, we propose that the interaction of anthramycin with DNA may also account for its action as a chemosterilant.

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Chemosterilant action of anthramycin: A proposed mechanism

Abstract

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