TY - JOUR
T1 - Characterization of the North American beaver (Castor canadensis) papillomavirus genome
AU - Rogovskyy, Artem S.
AU - Chen, Zigui
AU - Burk, Robert D.
AU - Bankhead, Troy
N1 - Funding Information:
This study was supported by an intramural grant provided by the College of Veterinary Medicine at Washington State University, Pullman, WA, USA .
Copyright:
Copyright 2020 Elsevier B.V., All rights reserved.
PY - 2014/1/10
Y1 - 2014/1/10
N2 - The papillomaviruses comprise a large group of viruses that cause proliferations of the stratified squamous epithelium of skin and mucosa in a variety of animals. An earlier report identified a novel papillomavirus of the North American beaver, Castor canadensis (CcanPV1) that was associated with cutaneous exophytic lesions. In the current study, we determined the sequence of the complete 7435 basepair genome of CcanPV1. The genome contains an Upstream Regulatory Region located between the end of L1 and the start of E6, and seven canonical papillomavirus open reading frames encoding five early (E6, E7, E1, E2, and E4) and two late (L2 and L1) proteins. No E5 open reading frame was detected. Phylogenetic analysis of the CcanPV1 genome places the virus between the genera Kappapapillomavirus and Mupapillomavirus. Analyses of the papillomavirus genomes detected in different species of the order Rodentia indicate these viruses do not form a monophyletic clade.
AB - The papillomaviruses comprise a large group of viruses that cause proliferations of the stratified squamous epithelium of skin and mucosa in a variety of animals. An earlier report identified a novel papillomavirus of the North American beaver, Castor canadensis (CcanPV1) that was associated with cutaneous exophytic lesions. In the current study, we determined the sequence of the complete 7435 basepair genome of CcanPV1. The genome contains an Upstream Regulatory Region located between the end of L1 and the start of E6, and seven canonical papillomavirus open reading frames encoding five early (E6, E7, E1, E2, and E4) and two late (L2 and L1) proteins. No E5 open reading frame was detected. Phylogenetic analysis of the CcanPV1 genome places the virus between the genera Kappapapillomavirus and Mupapillomavirus. Analyses of the papillomavirus genomes detected in different species of the order Rodentia indicate these viruses do not form a monophyletic clade.
KW - Castor canadensis papillomavirus
KW - CcanPV1
KW - North American beaver
KW - Papillomavirus
UR - http://www.scopus.com/inward/record.url?scp=84890804716&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84890804716&partnerID=8YFLogxK
U2 - 10.1016/j.vetmic.2013.11.011
DO - 10.1016/j.vetmic.2013.11.011
M3 - Article
C2 - 24309404
AN - SCOPUS:84890804716
SN - 0378-1135
VL - 168
SP - 214
EP - 220
JO - Veterinary Microbiology
JF - Veterinary Microbiology
IS - 1
ER -