TY - JOUR
T1 - Characteristics of the MACS/WIHS Combined Cohort Study
T2 - Opportunities for Research on Aging with HIV in the Longest US Observational Study of HIV
AU - D'Souza, Gypsyamber
AU - Bhondoekhan, Fiona
AU - Benning, Lorie
AU - Margolick, Joseph B.
AU - Adedimeji, Adebola A.
AU - Adimora, Adaora A.
AU - Alcaide, Maria L.
AU - Cohen, Mardge H.
AU - Detels, Roger
AU - Friedman, M. Reuel
AU - Holman, Susan
AU - Konkle-Parker, Deborah J.
AU - Merenstein, Daniel
AU - Ofotokun, Igho
AU - Palella, Frank
AU - Altekruse, Sean
AU - Brown, Todd T.
AU - Tien, Phyllis C.
N1 - Publisher Copyright:
© 2021.
PY - 2021/8/1
Y1 - 2021/8/1
N2 - In 2019, the National Institutes of Health combined the Multicenter AIDS Cohort Study (MACS) and the Women's Interagency HIV Study (WIHS) into the MACS/WIHS Combined Cohort Study (MWCCS). In this paper, participants who made a study visit during October 2018-September 2019 (targeted for MWCCS enrollment) are described by human immunodeficiency virus (HIV) serostatus and compared with people living with HIV (PLWH) in the United States. Participants include 2,115 women and 1,901 men with a median age of 56 years (interquartile range, 48-63); 62% are PLWH. Study sites encompass the South (18%), the Mid-Atlantic/Northeast (45%), the West Coast (22%), and the Midwest (15%). Participant race/ethnicity approximates that of PLWH throughout the United States. Longitudinal data and specimens collected for 35 years (men) and 25 years (women) were combined. Differences in data collection and coding were reviewed, and key risk factor and comorbidity data were harmonized. For example, recent use of alcohol (62%) and tobacco (28%) are common, as are dyslipidemia (64%), hypertension (56%), obesity (42%), mildly or severely impaired daily activities (31%), depressive symptoms (28%), and diabetes (22%). The MWCCS repository includes serum, plasma, peripheral blood mononuclear cells, cell pellets, urine, cervicovaginal lavage samples, oral samples, B-cell lines, stool, and semen specimens. Demographic differences between the MACS and WIHS can confound analyses by sex. The merged MWCCS is both an ongoing observational cohort study and a valuable resource for harmonized longitudinal data and specimens for HIV-related research.
AB - In 2019, the National Institutes of Health combined the Multicenter AIDS Cohort Study (MACS) and the Women's Interagency HIV Study (WIHS) into the MACS/WIHS Combined Cohort Study (MWCCS). In this paper, participants who made a study visit during October 2018-September 2019 (targeted for MWCCS enrollment) are described by human immunodeficiency virus (HIV) serostatus and compared with people living with HIV (PLWH) in the United States. Participants include 2,115 women and 1,901 men with a median age of 56 years (interquartile range, 48-63); 62% are PLWH. Study sites encompass the South (18%), the Mid-Atlantic/Northeast (45%), the West Coast (22%), and the Midwest (15%). Participant race/ethnicity approximates that of PLWH throughout the United States. Longitudinal data and specimens collected for 35 years (men) and 25 years (women) were combined. Differences in data collection and coding were reviewed, and key risk factor and comorbidity data were harmonized. For example, recent use of alcohol (62%) and tobacco (28%) are common, as are dyslipidemia (64%), hypertension (56%), obesity (42%), mildly or severely impaired daily activities (31%), depressive symptoms (28%), and diabetes (22%). The MWCCS repository includes serum, plasma, peripheral blood mononuclear cells, cell pellets, urine, cervicovaginal lavage samples, oral samples, B-cell lines, stool, and semen specimens. Demographic differences between the MACS and WIHS can confound analyses by sex. The merged MWCCS is both an ongoing observational cohort study and a valuable resource for harmonized longitudinal data and specimens for HIV-related research.
KW - HIV
KW - MACS/WIHS Combined Cohort Study
KW - Multicenter AIDS Cohort Study
KW - Women's Interagency HIV Study
KW - biorepositories
KW - cohort studies
KW - collaborative research
KW - comorbidity
UR - http://www.scopus.com/inward/record.url?scp=85113277242&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85113277242&partnerID=8YFLogxK
U2 - 10.1093/aje/kwab050
DO - 10.1093/aje/kwab050
M3 - Article
C2 - 33675224
AN - SCOPUS:85113277242
SN - 0002-9262
VL - 190
SP - 1457
EP - 1475
JO - American Journal of Epidemiology
JF - American Journal of Epidemiology
IS - 8
ER -