Chaperone-mediated autophagy regulates adipocyte differentiation

Susmita Kaushik, Yves R. Juste, Kristen Lindenau, Shuxian Dong, Adrián Macho-González, Olaya Santiago-Fernández, Mericka McCabe, Rajat Singh, Evripidis Gavathiotis, Ana Maria Cuervo

Research output: Contribution to journalArticlepeer-review

5 Scopus citations


Adipogenesis is a tightly orchestrated multistep process wherein preadipocytes differentiate into adipocytes. The most studied aspect of adipogenesis is its transcriptional regulation through timely expression and silencing of a vast number of genes. However, whether turnover of key regulatory proteins per se controls adipogenesis remains largely understudied. Chaperone-mediated autophagy (CMA) is a selective form of lysosomal protein degradation that, in response to diverse cues, remodels the proteome for regulatory purposes. We report here the activation of CMA during adipocyte differentiation and show that CMA regulates adipogenesis at different steps through timely degradation of key regulatory signaling proteins and transcription factors that dictate proliferation, energetic adaptation, and signaling changes required for adipogenesis.

Original languageEnglish (US)
Article numbereabq2733
JournalScience Advances
Issue number46
StatePublished - Nov 2022

ASJC Scopus subject areas

  • General


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