Channeling the homocysteine chapel

Research output: Contribution to journalComment/debatepeer-review

3 Scopus citations


Hyperhomocysteinemia (HHcy), a potent risk factor for cardiovascular disease, is associated with impaired endothelium-dependent vasodilation. In this issue of Blood, Cheng et al report that severe HHcy causes oxidation and tyrosine nitration of small and intermediate conductance Ca2+-activated potassium channels, resulting in impaired endothelium-derived hyperpolarizing factor (EDHF)-mediated relaxation of resistance arterioles.1.

Original languageEnglish (US)
Pages (from-to)1717-1719
Number of pages3
Issue number7
StatePublished - Aug 18 2011

ASJC Scopus subject areas

  • Biochemistry
  • Immunology
  • Hematology
  • Cell Biology


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