Changes in insulin-like growth factor-I and its binding proteins are associated with diabetes mellitus in older adults

Chino S. Aneke-Nash, Christina M. Parrinello, Swapnil N. Rajpathak, Thomas E. Rohan, Elsa S. Strotmeyer, Stephen B. Kritchevsky, Bruce M. Psaty, Petra Bůžková, Jorge R. Kizer, Anne B. Newman, Howard D. Strickler, Robert C. Kaplan

Research output: Contribution to journalArticlepeer-review

11 Scopus citations


Objectives To determine whether changes in insulin-like growth factor (IGF) protein levels are greater in participants with type 2 diabetes mellitus or worsening glycemia than in normoglycemic individuals over a 9-year follow-up period. Design Retrospective analysis of a cohort study. Setting Participants were recruited from North Carolina, California, Maryland, and Pennsylvania. Participants Cardiovascular Health Study All Stars participants, a cohort study of community-dwelling adults aged 65 and older (N = 897). Measurements Plasma IGF-I, IGF binding protein (IGFBP)-1, and IGFBP-3 levels were assessed and American Diabetes Association cut-points for impaired glucose tolerance (IGT), impaired fasting glucose (IFG), and diabetes mellitus were used to classify participants at baseline (1996-97) and follow-up (2005-06). Results At baseline, mean age was 76.3 ± 3.6, and 18.5% had diabetes mellitus. Participants with IFG alone and IGT plus IFG had higher IGF-I levels and lower IGFBP-1 levels than those with normoglycemia or diabetes mellitus. The greatest percentage change in IGF levels occurred in those who had diabetes mellitus at baseline (9-year changes: -9.3% for IGF-I, 59.7% for IGFBP-1, -13.4% for IGFBP-3), the smallest in individuals who remained normoglycemic at follow-up (9-year changes: -3.7% for IGF-I, 25.6% for IGFBP-1, -6.4% for IGFBP-3), and intermediate in those who were normoglycemic but developed IFG at follow-up. Conclusion Degrees of glycemic impairment are associated with varying degrees of change in IGF protein levels. The changes observed in the diabetes mellitus group have been previously shown to be associated with heart failure, cancer, and noncancer mortality.

Original languageEnglish (US)
Pages (from-to)902-909
Number of pages8
JournalJournal of the American Geriatrics Society
Issue number5
StatePublished - May 1 2015


  • diabetes mellitus
  • glycemic status
  • insulin-like growth factor

ASJC Scopus subject areas

  • Geriatrics and Gerontology


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