Changes caused by haloperidol are blocked by music in Wistar rat

Inmaculada Tasset, Ismael Quero, Ángel D. García-Mayórgaz, Manuel Causse Del Río, Isaac Túnez, Pedro Montilla

Research output: Contribution to journalArticlepeer-review

17 Scopus citations


This study sought to evaluate the effect of classical music, using Mozart's sonata for two pianos (K. 448), on changes in dopamine (DA) levels in the striatal nucleus (SN), prefrontal cortex (PFC) and mesencephalon, and on prolactin (PRL) and corticosterone secretion in adult male Wistar rats. Rats were divided into four groups: (1) control, (2) haloperidol treatment (single dose of 2 mg/kg s.c.), (3) music (two 2-h sessions per day) and (4) haloperidol plus music. Rats were sacrificed 2 h after haloperidol injection. Music prompted a fall in plasma PRL and corticosterone levels in healthy rats (P<0.05) and prevented the increase in levels triggered by haloperidol (P<0.001). Moreover, exposure to music was associated with a significant increase in DA levels in all groups, with the increase being particularly marked in PFC and SN (P<0.001). Haloperidol is a recognised D2 receptor antagonist, and these findings suggest that music, by contrast, enhances DA activity and turnover in the brain. The results obtained here bear out reports that music triggers a reduction in systolic pressure and an increase in mesencephalon dopamine levels in human and rats treated with ecstasy, through a calmodulin-dependent system.

Original languageEnglish (US)
Pages (from-to)175-179
Number of pages5
JournalJournal of Physiology and Biochemistry
Issue number2
StatePublished - Jun 2012
Externally publishedYes


  • Corticosterone
  • Dopaminergic system
  • Haloperidol
  • Prolactin
  • Sonata to piano K. 488

ASJC Scopus subject areas

  • Physiology
  • Biochemistry


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