TY - JOUR
T1 - Cervical infection with cutaneous beta and mucosal alpha papillomaviruses
AU - Ludwig-McGill Cohort Study
AU - Sichero, Laura
AU - Sichero, Laura
AU - Nunes, Emily M.
AU - Ferreira, Silvaneide
AU - Franco, Eduardo L.
AU - Villa, Luisa L.
AU - Baggio, Maria Luiza
AU - Galan, Lenice
AU - Sobrinho, João Simão
AU - Prado, José Carlos Mann
AU - Termini, Lara
AU - Costa, Maria Cecília
AU - Miyamura, Romulo
AU - Trevisan, Andrea
AU - Thomann, Patricia
AU - Candeias, João
AU - Rahal, Paula
AU - Ruiz, Antonio
AU - Kaiano, Jane
AU - Santos, Monica
AU - Savio, Patricia
AU - Maciag, Paulo
AU - Rabachini, Tatiana
AU - Rousseau, Marie Claude
AU - Mahmud, Salaheddin
AU - Schlecht, Nicolas
AU - Trottier, Helen
AU - Richardson, Harriet
AU - Ferenczy, Alex
AU - Rohan, Thomas
AU - Chevarie-Davis, Myriam
AU - Louvanto, Karolina
AU - Tota, Joseph
AU - Shaw, Eileen
AU - Ramanakumar, Agnihotram
AU - Duarte, Eliane
AU - Kulaga, Sophie
AU - Robitaille, Juliette
N1 - Publisher Copyright:
© 2017 American Association for Cancer Research.
PY - 2017/8/1
Y1 - 2017/8/1
N2 - Background: Alpha-human papillomavirus (α-HPV) plays a causal role in cervical cancer, but little is known about the epidemiology of genital Beta-human papillomavirus (β-HPV) infection. Methods: We used Luminex and PCR hybridization to detect band α-HPVs prevalence at enrollment and 12-month follow-up in cervical samples from 505 women enrolled in the Ludwig-McGill cohort study. We compared epidemiologic correlates of both band α-HPVs and compared genotypes between these genera with respect to co-occurrence and association with cervical cytologic abnormalities. Results: Infection with β-HPV types was more prevalent than that with α-HPV types at both visits (cumulative prevalences: 27.3% vs. 21.6%, respectively, P = 0.034). β-HPVs were mostly transient; however, only 1.98% women retained their original positivity at 12 months, whereas persistence was higher for α-HPVs (5.15%; P = 0.007). Age, parity, and sexual activity variables were predictors of α-HPV but not of β-HPV. α- and β-HPV types occurred independently. Increased risk of cervical abnormalities was restricted to women infected with a-9 or a-6 HPV types. We found no epidemiologic correlates for β-HPV infections. Conclusions: Detection of β-HPV types in the cervix tends to occur as random and transient episodes not explained via the sexual-transmission correlates that characterize infections by α-HPVs. Impact: Although it is plausible that β-HPVs may play a direct or indirect carcinogenic role, the lack of epidemiologic correlates for detection episodes of these viruses and lack of association with cervical lesions speak against their ancillary role as sexually transmitted agents in cervical carcinogenesis. Cancer Epidemiol Biomarkers Prev; 26(8); 1312-20.
AB - Background: Alpha-human papillomavirus (α-HPV) plays a causal role in cervical cancer, but little is known about the epidemiology of genital Beta-human papillomavirus (β-HPV) infection. Methods: We used Luminex and PCR hybridization to detect band α-HPVs prevalence at enrollment and 12-month follow-up in cervical samples from 505 women enrolled in the Ludwig-McGill cohort study. We compared epidemiologic correlates of both band α-HPVs and compared genotypes between these genera with respect to co-occurrence and association with cervical cytologic abnormalities. Results: Infection with β-HPV types was more prevalent than that with α-HPV types at both visits (cumulative prevalences: 27.3% vs. 21.6%, respectively, P = 0.034). β-HPVs were mostly transient; however, only 1.98% women retained their original positivity at 12 months, whereas persistence was higher for α-HPVs (5.15%; P = 0.007). Age, parity, and sexual activity variables were predictors of α-HPV but not of β-HPV. α- and β-HPV types occurred independently. Increased risk of cervical abnormalities was restricted to women infected with a-9 or a-6 HPV types. We found no epidemiologic correlates for β-HPV infections. Conclusions: Detection of β-HPV types in the cervix tends to occur as random and transient episodes not explained via the sexual-transmission correlates that characterize infections by α-HPVs. Impact: Although it is plausible that β-HPVs may play a direct or indirect carcinogenic role, the lack of epidemiologic correlates for detection episodes of these viruses and lack of association with cervical lesions speak against their ancillary role as sexually transmitted agents in cervical carcinogenesis. Cancer Epidemiol Biomarkers Prev; 26(8); 1312-20.
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U2 - 10.1158/1055-9965.EPI-17-0081
DO - 10.1158/1055-9965.EPI-17-0081
M3 - Article
C2 - 28377417
AN - SCOPUS:85021936596
SN - 1055-9965
VL - 26
SP - 1312
EP - 1320
JO - Cancer Epidemiology Biomarkers and Prevention
JF - Cancer Epidemiology Biomarkers and Prevention
IS - 8
ER -