Cerebral saturations trend with mixed venous saturations in patients undergoing extracorporeal life support

Clifford L. Cua, Timothy M. Hoffman, Roozbeh Taeed, Samuel Weinstein, Daniel Gomez, Vincent F. Olshove, Josepha M. Craenen

Research output: Contribution to journalArticlepeer-review

8 Scopus citations


Cerebral saturation (SCO2) monitors are noninvasive tools that continuously measure saturations in the cerebral cortex, a predominately venous bed. The purpose of this study was to see if a trend existed between measurements of SCO2 and mixed venous saturation values (SVO2) for patients on extracorporeal life support (ECLS). Six patients required ECLS for cardiac failure after congenital cardiac surgery, and one patient required ECLS for pulmonary failure. Patients were divided into two groups, those without systemic/pulmonary venous mixing (n=3, Group I) and those with mixing due to an intra-atrial shunt or left ventricular vent (n=4, Group II). The age of patients was 0.4±0.5 years (mean±SD), weight was 5.2±2.3 kg, and time on ECLS was 8.3±4.8 days. No significant abnormalities were seen on head imaging. A total of 786 paired data points were collected. Mean values were different; however, there was a significant trend between SCO2 and SVO2 for the entire sample (R2=0.66, p <0.001). Cerebral saturation trends follow mixed venous trends and, therefore, may be helpful in combination with other physical and laboratory findings in the care of the critically ill child.

Original languageEnglish (US)
Pages (from-to)171-176
Number of pages6
Issue number3
StatePublished - 2004
Externally publishedYes


  • Cardiac output
  • Cerebral saturation
  • Extracorporeal life support
  • Mixed venous saturation

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Safety Research
  • Cardiology and Cardiovascular Medicine
  • Advanced and Specialized Nursing


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