Cerebral ischemia and mitral valve prolapse: Case-control study of associated factors

Roger E. Kelley, Ileana Pina, Shih Chang Lee

Research output: Contribution to journalArticlepeer-review

15 Scopus citations


We evaluated 36 patients with cerebral ischemia and mitral valve prolapse and compared them with 36 age-matched controls with cerebral ischemia who had similar attributes but who did not have mitral valve prolapse. Stepwise logistic regression analysis revealed an inverse relation between cerebral ischemia in the presence of mitral valve prolapse and hypertension, diabetes mellitus, occlusive cerebrovascular disease, and completed stroke at p<0.01. We also found, by correlation analysis, a negative correlation between both hypertension and diabetes mellitus versus mitral valve prolapse at p<0.05. Overall, 10 study patients compared with two control patients had no risk factors for cerebrovascular disease detected (?2 = 4.9, p<0.05). These data indicate that the association of mitral valve prolapse and cerebral ischemia is of special importance in patients who do not have other detected risk factors for cerebrovascular disease.

Original languageEnglish (US)
Pages (from-to)443-446
Number of pages4
Issue number4
StatePublished - Apr 1988


  • Cerebral ischemia
  • Mitral valve prolapsed
  • Risk factors

ASJC Scopus subject areas

  • Clinical Neurology
  • Cardiology and Cardiovascular Medicine
  • Advanced and Specialized Nursing


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