Cerebral germinomas and klinefelter syndrome. A review

Raanan Arens, Daniel Marcus, Santiago Engelberg, Gideon Findler, Richard M. Goodman, Justen H. Passwell

Research output: Contribution to journalArticlepeer-review

40 Scopus citations


Patients with Klinefelter syndrome appear to be predisposed to the development of extragonadal cerebral germinomas. A case of a pineal region germinoma in a boy 15 years of age with Klinefelter syndrome is documented in this article. In view of three other cases of cerebral germinomas associated with Klinefelter syndrome in the literature, a hypothesis for this predisposition is suggested.

Original languageEnglish (US)
Pages (from-to)1228-1231
Number of pages4
Issue number6
StatePublished - Mar 15 1988
Externally publishedYes

ASJC Scopus subject areas

  • Oncology
  • Cancer Research


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