TY - JOUR
T1 - Cellular immune suppression in paraneoplastic neurologic syndromes targeting intracellular antigens
AU - Orange, Dana
AU - Frank, Mayu
AU - Tian, Suyan
AU - Dousmanis, Athanasios
AU - Marmur, Ronen
AU - Buckley, Noreen
AU - Parveen, Salina
AU - Graber, Jerome J.
AU - Blachère, Nathalie
AU - Darnell, Robert B.
PY - 2012/9
Y1 - 2012/9
N2 - Background: Tumor treatment is the mainstay of therapy for paraneoplastic neurologic disorders (PNDs), but it is only effective in some cases and other treatment options are limited. Objective: To evaluate the short-term use of a combination of prednisone and tacrolimus for acute neurologic worsening in PND in which intracellular antigens are targeted. Design: Retrospective single-center case series of patients with PND treated with tacrolimus. Setting: The Rockefeller University Hospital, a research hospital in New York, New York. Patients: Twenty-six patients with PND with high titer (≥1:1000) anti-HuD, anti-Yo, or anti-CRMP5 autoantibodies were enrolled. Patients were referred from Memorial Sloan Kettering Cancer Center or self-referred. Two patients discontinued intervention owing to adverse events. Interventions: Patients were treated with tacrolimus, 0.15-0.30 mg/kg per day, in 2 divided oral doses with 60 mg per day of oral prednisone, tapered off during 1 to 4 weeks. Main Outcome Measures: The primary outcome measure was median survival. Neurologic examinations before and after treatment as well as adverse events are described. Results: Median survival time was 52 months from time of diagnosis. Some patients experienced neurologic improvement that was functionally meaningful. The incidence of adverse events was similar to that generally reported with tacrolimus. Conclusions: A short course of prednisone and tacrolimus to target central nervous system T cells in patients with PND with acute neurologic decline in which intracellular antigens are targeted was well tolerated and warrants further study.
AB - Background: Tumor treatment is the mainstay of therapy for paraneoplastic neurologic disorders (PNDs), but it is only effective in some cases and other treatment options are limited. Objective: To evaluate the short-term use of a combination of prednisone and tacrolimus for acute neurologic worsening in PND in which intracellular antigens are targeted. Design: Retrospective single-center case series of patients with PND treated with tacrolimus. Setting: The Rockefeller University Hospital, a research hospital in New York, New York. Patients: Twenty-six patients with PND with high titer (≥1:1000) anti-HuD, anti-Yo, or anti-CRMP5 autoantibodies were enrolled. Patients were referred from Memorial Sloan Kettering Cancer Center or self-referred. Two patients discontinued intervention owing to adverse events. Interventions: Patients were treated with tacrolimus, 0.15-0.30 mg/kg per day, in 2 divided oral doses with 60 mg per day of oral prednisone, tapered off during 1 to 4 weeks. Main Outcome Measures: The primary outcome measure was median survival. Neurologic examinations before and after treatment as well as adverse events are described. Results: Median survival time was 52 months from time of diagnosis. Some patients experienced neurologic improvement that was functionally meaningful. The incidence of adverse events was similar to that generally reported with tacrolimus. Conclusions: A short course of prednisone and tacrolimus to target central nervous system T cells in patients with PND with acute neurologic decline in which intracellular antigens are targeted was well tolerated and warrants further study.
UR - http://www.scopus.com/inward/record.url?scp=84866141837&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84866141837&partnerID=8YFLogxK
U2 - 10.1001/archneurol.2012.595
DO - 10.1001/archneurol.2012.595
M3 - Article
C2 - 22566506
AN - SCOPUS:84866141837
SN - 0003-9942
VL - 69
SP - 1132
EP - 1140
JO - Archives of Neurology
JF - Archives of Neurology
IS - 9
ER -