Cell type-specific pharmacology of NMDA receptors using masked MK801

Yunlei Yang; Peter Lee; Scott M. Sternson

doi:10.7554/eLife.10206

Cell type-specific pharmacology of NMDA receptors using masked MK801

Yunlei Yang, Peter Lee, Scott M. Sternson

Research output: Contribution to journal › Article › peer-review

13 Scopus citations

Abstract

N-Methyl-D-aspartate receptors (NMDA-Rs) are ion channels that are important for synaptic plasticity, which is involved in learning and drug addiction. We show enzymatic targeting of an NMDA-R antagonist, MK801, to a molecularly defined neuronal population with the cell-type-selectivity of genetic methods and the temporal control of pharmacology. We find that NMDA-Rs on dopamine neurons are necessary for cocaine-induced synaptic potentiation, demonstrating that cell type-specific pharmacology can be used to dissect signaling pathways within complex brain circuits.

Original language	English (US)
Article number	e10206
Journal	eLife
Volume	4
Issue number	September 2015
DOIs	https://doi.org/10.7554/eLife.10206
State	Published - Sep 11 2015
Externally published	Yes

ASJC Scopus subject areas

General Immunology and Microbiology
General Biochemistry, Genetics and Molecular Biology
General Neuroscience

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.7554/eLife.10206

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AB - N-Methyl-D-aspartate receptors (NMDA-Rs) are ion channels that are important for synaptic plasticity, which is involved in learning and drug addiction. We show enzymatic targeting of an NMDA-R antagonist, MK801, to a molecularly defined neuronal population with the cell-type-selectivity of genetic methods and the temporal control of pharmacology. We find that NMDA-Rs on dopamine neurons are necessary for cocaine-induced synaptic potentiation, demonstrating that cell type-specific pharmacology can be used to dissect signaling pathways within complex brain circuits.

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Cell type-specific pharmacology of NMDA receptors using masked MK801

Abstract

ASJC Scopus subject areas

UN SDGs

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