Cell migration in tumors

Hideki Yamaguchi, Jeffrey Wyckoff, John Condeelis

Research output: Contribution to journalReview articlepeer-review

614 Scopus citations


Invasion of cancer cells into surrounding tissue and the vasculature is an initial step in tumor metastasis. This requires chemotactic migration of cancer cells, steered by protrusive activity of the cell membrane and its attachment to the extracellular matrix. Recent advances in intravital imaging and the development of an in vivo invasion assay have provided new insights into how cancer cell migration is regulated by elements of the local microenvironment, including the extracellular matrix architecture and other cell types found in primary tumors. These results, combined with new findings from in vitro studies, have led to new insights into the molecular mechanisms of cell protrusive activity and chemotactic migration during invasion and metastasis.

Original languageEnglish (US)
Pages (from-to)559-564
Number of pages6
JournalCurrent Opinion in Cell Biology
Issue number5 SPEC. ISS.
StatePublished - Oct 2005

ASJC Scopus subject areas

  • Cell Biology


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