Cell adhesion molecules: Signalling functions at the synapse

Matthew B. Dalva, Andrew C. McClelland, Matthew S. Kayser

Research output: Contribution to journalReview articlepeer-review

448 Scopus citations


Many cell adhesion molecules are localized at synaptic sites in neuronal axons and dendrites. These molecules bridge pre- and postsynaptic specializations but do far more than simply provide a mechanical link between cells. In this review, we will discuss the roles these proteins have during development and at mature synapses. Synaptic adhesion proteins participate in the formation, maturation, function and plasticity of synaptic connections. Together with conventional synaptic transmission mechanisms, these molecules are an important element in the trans-cellular communication mediated by synapses.

Original languageEnglish (US)
Pages (from-to)206-220
Number of pages15
JournalNature Reviews Neuroscience
Issue number3
StatePublished - Mar 2007
Externally publishedYes

ASJC Scopus subject areas

  • General Neuroscience


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