C/EBPβ is a negative regulator of human papillomavirus type 11 in keratinocytes

Hao Wang, Kai Liu, Fang Yuan, Lillian Berdichevsky, Lorne B. Taichman, Karen Auborn

Research output: Contribution to journalArticlepeer-review

44 Scopus citations


We have evaluated the impact of the CCAAT enhancer-binding protein (C/EBP) transcription factors on human papillomavirus type 11 (HPV11). C/EBPβ is in nuclei of cultured foreskin keratinocytes and hinds its consensus sequence in HPV11 DNA. We have used the novel approach of depleting the availability of C/EBPs in vivo using nuclease-resistant oligomers containing C/EBP DNA binding sites. In cultured foreskin keratinocytes containing replicating HPV11 DNA, levels of both HPV11 transcripts and HPV DNA increase after treatment with oligomers containing the C/EBPβ DNA binding motif. These results indicate that C/EBPβ is a repressor for HPV11 in keratinocytes.

Original languageEnglish (US)
Pages (from-to)4839-4844
Number of pages6
JournalJournal of virology
Issue number7
StatePublished - 1996
Externally publishedYes

ASJC Scopus subject areas

  • Microbiology
  • Immunology
  • Insect Science
  • Virology


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