CCR5 expression levels in HIV-uninfected women receiving hormonal contraception

Gaia Sciaranghella; Cuiwei Wang; Haihong Hu; Kathryn Anastos; Zaher Merhi; Marek Nowicki; Frank Z. Stanczyk; Ruth M. Greenblatt; Mardge Cohen; Elizabeth T. Golub; D. Heather Watts; Galit Alter; Mary A. Young; Athe M.N. Tsibris

doi:10.1093/infdis/jiv233

CCR5 expression levels in HIV-uninfected women receiving hormonal contraception

Gaia Sciaranghella, Cuiwei Wang, Haihong Hu, Kathryn Anastos, Zaher Merhi, Marek Nowicki, Frank Z. Stanczyk, Ruth M. Greenblatt, Mardge Cohen, Elizabeth T. Golub, D. Heather Watts, Galit Alter, Mary A. Young, Athe M.N. Tsibris

Medicine

Research output: Contribution to journal › Article › peer-review

23 Scopus citations

Abstract

Human immunodeficiency virus (HIV) infectivity increases as receptor/coreceptor expression levels increase. We determined peripheral CD4, CCR5, and CXCR4 expression levels in HIV-uninfected women who used depot medroxyprogesterone acetate (DMPA; n = 32), the levonorgestrel-releasing intrauterine device (LNG-IUD; n = 27), oral contraceptive pills (n = 32), or no hormonal contraception (n = 33). The use of LNG-IUD increased the proportion of CD4⁺ and CD8⁺ T cells that expressed CCR5; increases in the magnitude of T-cell subset CCR5 expression were observed with DMPA and LNG-IUD use (P <. 01 for all comparisons). LNG-IUD and, to a lesser extent, DMPA use were associated with increased peripheral T-cell CCR5 expression.

Original language	English (US)
Pages (from-to)	1397-1401
Number of pages	5
Journal	Journal of Infectious Diseases
Volume	212
Issue number	9
DOIs	https://doi.org/10.1093/infdis/jiv233
State	Published - Nov 1 2015

Keywords

CCR5
CD4
CXCR4
HIV-1
hormonal contraception
levonorgestrel
medroxyprogesterone acetate
oral contraceptive pills
peripheral blood mononuclear cells

ASJC Scopus subject areas

General Medicine

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1093/infdis/jiv233

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Sciaranghella, G., Wang, C., Hu, H., Anastos, K., Merhi, Z., Nowicki, M., Stanczyk, F. Z., Greenblatt, R. M., Cohen, M., Golub, E. T., Watts, D. H., Alter, G., Young, M. A., & Tsibris, A. M. N. (2015). CCR5 expression levels in HIV-uninfected women receiving hormonal contraception. Journal of Infectious Diseases, 212(9), 1397-1401. https://doi.org/10.1093/infdis/jiv233

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title = "CCR5 expression levels in HIV-uninfected women receiving hormonal contraception",

abstract = "Human immunodeficiency virus (HIV) infectivity increases as receptor/coreceptor expression levels increase. We determined peripheral CD4, CCR5, and CXCR4 expression levels in HIV-uninfected women who used depot medroxyprogesterone acetate (DMPA; n = 32), the levonorgestrel-releasing intrauterine device (LNG-IUD; n = 27), oral contraceptive pills (n = 32), or no hormonal contraception (n = 33). The use of LNG-IUD increased the proportion of CD4+ and CD8+ T cells that expressed CCR5; increases in the magnitude of T-cell subset CCR5 expression were observed with DMPA and LNG-IUD use (P <. 01 for all comparisons). LNG-IUD and, to a lesser extent, DMPA use were associated with increased peripheral T-cell CCR5 expression.",

keywords = "CCR5, CD4, CXCR4, HIV-1, hormonal contraception, levonorgestrel, medroxyprogesterone acetate, oral contraceptive pills, peripheral blood mononuclear cells",

author = "Gaia Sciaranghella and Cuiwei Wang and Haihong Hu and Kathryn Anastos and Zaher Merhi and Marek Nowicki and Stanczyk, {Frank Z.} and Greenblatt, {Ruth M.} and Mardge Cohen and Golub, {Elizabeth T.} and Watts, {D. Heather} and Galit Alter and Young, {Mary A.} and Tsibris, {Athe M.N.}",

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AU - Nowicki, Marek

AU - Stanczyk, Frank Z.

AU - Greenblatt, Ruth M.

AU - Cohen, Mardge

AU - Golub, Elizabeth T.

AU - Watts, D. Heather

AU - Alter, Galit

AU - Young, Mary A.

AU - Tsibris, Athe M.N.

N1 - Publisher Copyright: © The Author 2015. Published by Oxford University Press on behalf of the Infectious Diseases Society of America.

PY - 2015/11/1

Y1 - 2015/11/1

N2 - Human immunodeficiency virus (HIV) infectivity increases as receptor/coreceptor expression levels increase. We determined peripheral CD4, CCR5, and CXCR4 expression levels in HIV-uninfected women who used depot medroxyprogesterone acetate (DMPA; n = 32), the levonorgestrel-releasing intrauterine device (LNG-IUD; n = 27), oral contraceptive pills (n = 32), or no hormonal contraception (n = 33). The use of LNG-IUD increased the proportion of CD4+ and CD8+ T cells that expressed CCR5; increases in the magnitude of T-cell subset CCR5 expression were observed with DMPA and LNG-IUD use (P <. 01 for all comparisons). LNG-IUD and, to a lesser extent, DMPA use were associated with increased peripheral T-cell CCR5 expression.

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KW - CXCR4

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KW - peripheral blood mononuclear cells

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CCR5 expression levels in HIV-uninfected women receiving hormonal contraception

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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