TY - JOUR
T1 - Catheter related sepsis during long-term parenteral nutrition in paediatric gastroenterology patients
T2 - a study of 185 consecutive central venous catheters
AU - Goulet, O.
AU - Larchet, M.
AU - Gaillard, J. L.
AU - Goulet, V.
AU - Jan, D.
AU - Revillon, Y.
AU - Lortat-Jacob, S.
AU - Descamps, P.
AU - Ricour, C.
PY - 1990/4
Y1 - 1990/4
N2 - We report the results of a prospective study of catheter-related sepsis (CRS) in 154 gastroenterology paediatric patients treated for medical (n = 102) or surgical (n = 52) disorders. Over 2 years, 185 central venous catheters (CVC) were placed, including 155 Broviac and 30 Jonathan Shaw CVC. CVC remained in place 13,331 days (6,539 days of cyclic parenteral nutrition), with a mean catheter life of 72 days. Forty-eight episodes of CRS occurred, most of them due to coagulase-negative staphylococci (n = 29) and Staphylococcus aureus (n = 17). CRS rate was 0.26, with an overall incidence of 1 infection per 278 days of parenteral nutrition (PN). Factors significantly associated with CRS were: age 1-5 years (p < 0.01), a medical indication for treatment (p < 0.001) and summer months of PN (p < 0.01). Interestingly, CRS occurred predominantly (65%) within the first 2 months following CVC placement and the risk of infection correlated with local haemorrhage at the time of insertion (p < 0.01). Appropriate systemic therapy, without removing the catheter, permitted resolution of 90.9% ( 40 44) of all CRS and 100% ( 28 28) of CRS due to coagulase-negative staphylococci.
AB - We report the results of a prospective study of catheter-related sepsis (CRS) in 154 gastroenterology paediatric patients treated for medical (n = 102) or surgical (n = 52) disorders. Over 2 years, 185 central venous catheters (CVC) were placed, including 155 Broviac and 30 Jonathan Shaw CVC. CVC remained in place 13,331 days (6,539 days of cyclic parenteral nutrition), with a mean catheter life of 72 days. Forty-eight episodes of CRS occurred, most of them due to coagulase-negative staphylococci (n = 29) and Staphylococcus aureus (n = 17). CRS rate was 0.26, with an overall incidence of 1 infection per 278 days of parenteral nutrition (PN). Factors significantly associated with CRS were: age 1-5 years (p < 0.01), a medical indication for treatment (p < 0.001) and summer months of PN (p < 0.01). Interestingly, CRS occurred predominantly (65%) within the first 2 months following CVC placement and the risk of infection correlated with local haemorrhage at the time of insertion (p < 0.01). Appropriate systemic therapy, without removing the catheter, permitted resolution of 90.9% ( 40 44) of all CRS and 100% ( 28 28) of CRS due to coagulase-negative staphylococci.
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U2 - 10.1016/0261-5614(90)90056-X
DO - 10.1016/0261-5614(90)90056-X
M3 - Article
C2 - 16837335
AN - SCOPUS:0025215742
SN - 0261-5614
VL - 9
SP - 73
EP - 78
JO - Clinical Nutrition
JF - Clinical Nutrition
IS - 2
ER -