@article{98a50fc26ba44dd0bdbacf6cc0c3cfb6,
title = "Cases in precision medicine: APOL1 and genetic testing in the evaluation of chronic kidney disease and potential transplant",
abstract = "This article discusses potential indications for genetic testing in an African American patient with chronic kidney disease who is being evaluated for a kidney transplant. Two known risk variants in the APOL1 (apolipoprotein L1) gene predispose to kidney disease and are found almost exclusively in persons of African ancestry. APOL1 risk variants are considered, including whether clinicians should incorporate genetic testing in the screening process for living kidney donors. In addition to APOL1 testing, The role of diagnostic exome sequencing in evaluating potential transplant recipients and donors with a positive family history of kidney disease is discussed.",
author = "{Dana Neugut}, Y. and Sumit Mohan and Gharavi, {Ali G.} and Krzysztof Kiryluk",
note = "Funding Information: Grant Support: This work was supported by the Columbia Precision Medicine Initiative, Columbia University, as well as the following NIH grants: Columbia Clinical and Translational Science Award grant UL1TR001873 from the National Center for Advancing Translational Sciences (NCATS), Electronic Medical Records and Genomics (eMERGE) Network grant U01HG8680 from the National Human Genome Research Institute (NHGRI), APOL1 Long-Term Kidney Transplantation Outcomes Network (APOLLO) grant U01DK116066, Columbia Kidney Precision Medicine Project (KPMP) grant UG3DK114926, and training supplement T32-DK108741-02S1 from the National Institute of Diabetes and Digestive Kidney Diseases (NIDDK). Publisher Copyright: {\textcopyright} 2019 American College of Physicians",
year = "2019",
month = nov,
day = "5",
doi = "10.7326/M19-1389",
language = "English (US)",
volume = "171",
pages = "659--664",
journal = "Annals of internal medicine",
issn = "0003-4819",
publisher = "American College of Physicians",
number = "9",
}