Abstract
The cardiovascular effects of midazolam (0.15 mg kg-) and thiopentone (3.0 mg kg1) were compared during induction of anaesthesia in 20 American Society of Anesthesiologists class HI patients. In patients given thiopentone (N = 11), cardiac output, mean arterial pressure, heart rate, and systemic vascular resistance all decreased significantly over the course of the study period; mean right atrial pressure rose slightly, and stroke volume remained the same. Patients receiving midazolam (N = 9) experienced similar haemodynamic changes which were significant relative to baseline only for the fall in mean arterial pressure and the rise in mean right atrial pressure at ten minutes. There were no significant differences between the two groups. Midazolam thus appears to be at least as acceptable an induction agent as thiopentone in ill patients, from a haemoaynamic point of view.
Original language | English (US) |
---|---|
Pages (from-to) | 19-23 |
Number of pages | 5 |
Journal | Canadian Anaesthetists' Society Journal |
Volume | 30 |
Issue number | 1 |
DOIs | |
State | Published - Jan 1983 |
Externally published | Yes |
Keywords
- Anaesthetics
- Intravenous: midazolam
- blood pressure: drug effects
- drug effects
- heart: cardiac output
- thiopentone
ASJC Scopus subject areas
- Anesthesiology and Pain Medicine