Cancer treatment and the ovary: The effects of chemotherapy and radiation

Laurie E. Cohen

doi:10.1196/annals.1429.023

Cancer treatment and the ovary: The effects of chemotherapy and radiation

Laurie E. Cohen

Research output: Contribution to journal › Article › peer-review

19 Scopus citations

Abstract

Certain chemotherapeutic drugs ("alkylators") and radiation therapy are toxic to the ovaries, leading to both loss of sex steroid hormone production and infertility. Higher doses and older age at treatment are both associated with greater damage. Even patients with spontaneous menstrual cycles have evidence of decreased ovarian potential. Adolescents who are treated for cancer with these agents should be counseled about future fertility risks.

Original language	English (US)
Pages (from-to)	123-125
Number of pages	3
Journal	Annals of the New York Academy of Sciences
Volume	1135
DOIs	https://doi.org/10.1196/annals.1429.023
State	Published - Jun 2008
Externally published	Yes

Keywords

Bone marrow transplant
Chemotherapy
Premature ovarian failure
Radiation

ASJC Scopus subject areas

General Neuroscience
General Biochemistry, Genetics and Molecular Biology
History and Philosophy of Science

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1196/annals.1429.023

Cite this

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AB - Certain chemotherapeutic drugs ("alkylators") and radiation therapy are toxic to the ovaries, leading to both loss of sex steroid hormone production and infertility. Higher doses and older age at treatment are both associated with greater damage. Even patients with spontaneous menstrual cycles have evidence of decreased ovarian potential. Adolescents who are treated for cancer with these agents should be counseled about future fertility risks.

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KW - Chemotherapy

KW - Premature ovarian failure

KW - Radiation

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Cancer treatment and the ovary: The effects of chemotherapy and radiation

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

Access to Document

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