Cancer treatment and the ovary: The effects of chemotherapy and radiation

Research output: Contribution to journalArticlepeer-review

18 Scopus citations


Certain chemotherapeutic drugs ("alkylators") and radiation therapy are toxic to the ovaries, leading to both loss of sex steroid hormone production and infertility. Higher doses and older age at treatment are both associated with greater damage. Even patients with spontaneous menstrual cycles have evidence of decreased ovarian potential. Adolescents who are treated for cancer with these agents should be counseled about future fertility risks.

Original languageEnglish (US)
Pages (from-to)123-125
Number of pages3
JournalAnnals of the New York Academy of Sciences
StatePublished - Jun 2008
Externally publishedYes


  • Bone marrow transplant
  • Chemotherapy
  • Premature ovarian failure
  • Radiation

ASJC Scopus subject areas

  • General Neuroscience
  • General Biochemistry, Genetics and Molecular Biology
  • History and Philosophy of Science


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