TY - JOUR
T1 - Can unsupervised cluster analysis identify patterns of complex adult spinal deformity with distinct perioperative outcomes?
AU - on behalf of the International Spine Study Group
AU - Lafage, Renaud
AU - Fourman, Mitchell S.
AU - Smith, Justin S.
AU - Bess, Shay
AU - Shaffrey, Christopher I.
AU - Kim, Han Jo
AU - Kebaish, Khaled M.
AU - Burton, Douglas C.
AU - Hostin, Richard
AU - Passias, Peter G.
AU - Protopsaltis, Themistocles S.
AU - Daniels, Alan H.
AU - Klineberg, Eric O.
AU - Gupta, Munish C.
AU - Kelly, Michael P.
AU - Lenke, Lawrence G.
AU - Schwab, Frank J.
AU - Lafage, Virginie
N1 - Publisher Copyright:
©AANS 2023, except where prohibited by US copyright law.
PY - 2023/5
Y1 - 2023/5
N2 - OBJECTIVE The objective of this study was to use an unsupervised cluster approach to identify patterns of operative adult spinal deformity (ASD) and compare the perioperative outcomes of these groups. METHODS A multicenter data set included patients with complex surgical ASD, including those with severe deformities, significant surgical complexity, or advanced age who underwent a multilevel fusion. An unsupervised cluster analysis allowing for 10% outliers was used to identify different deformity patterns. The perioperative outcomes of these clusters were then compared using ANOVA, Kruskal-Wallis, and chi-square tests, with p values < 0.05 considered significant. RESULTS Two hundred eighty-six patients were classified into four clusters of deformity patterns: hyper-thoracic kyphosis (hyper-TK), severe coronal, severe sagittal, and moderate sagittal. Hyper-TK patients had the lowest disability (mean Oswestry Disability Index [ODI] 32.9 ± 17.1) and pain scores (median numeric rating scale [NRS] back score 6, leg score 1). The severe coronal cluster had moderate functional impairment (mean physical component score 34.4 ± 12.3) and pain (median NRS back score 7, leg score 4) scores. The severe sagittal cluster had the highest levels of disability (mean ODI 49.3 ± 15.6) and low appearance scores (mean 2.3 ± 0.7). The moderate cluster (mean 68.8 ± 7.8 years) had the highest pain interference subscores on the Patient-Reported Outcomes Measurement Information System (mean 65.2 ± 5.8). Overall 30-day adverse events were equivalent among the four groups. Fusion to the pelvis was most common in the moderate sagittal (89.4%) and severe sagittal (97.5%) clusters. The severe coronal cluster had more osteotomies per case (median 11, IQR 6.5-14) and a higher rate of 30-day implant-related complications (5.5%). The severe sagittal and hyper-TK clusters had more three-column osteotomies (43% and 32.3%, respectively). Hyper-TK patients had shorter hospital stays. CONCLUSIONS This cohort of patients with complex ASD surgeries contained four natural clusters of deformity, each with distinct perioperative outcomes.
AB - OBJECTIVE The objective of this study was to use an unsupervised cluster approach to identify patterns of operative adult spinal deformity (ASD) and compare the perioperative outcomes of these groups. METHODS A multicenter data set included patients with complex surgical ASD, including those with severe deformities, significant surgical complexity, or advanced age who underwent a multilevel fusion. An unsupervised cluster analysis allowing for 10% outliers was used to identify different deformity patterns. The perioperative outcomes of these clusters were then compared using ANOVA, Kruskal-Wallis, and chi-square tests, with p values < 0.05 considered significant. RESULTS Two hundred eighty-six patients were classified into four clusters of deformity patterns: hyper-thoracic kyphosis (hyper-TK), severe coronal, severe sagittal, and moderate sagittal. Hyper-TK patients had the lowest disability (mean Oswestry Disability Index [ODI] 32.9 ± 17.1) and pain scores (median numeric rating scale [NRS] back score 6, leg score 1). The severe coronal cluster had moderate functional impairment (mean physical component score 34.4 ± 12.3) and pain (median NRS back score 7, leg score 4) scores. The severe sagittal cluster had the highest levels of disability (mean ODI 49.3 ± 15.6) and low appearance scores (mean 2.3 ± 0.7). The moderate cluster (mean 68.8 ± 7.8 years) had the highest pain interference subscores on the Patient-Reported Outcomes Measurement Information System (mean 65.2 ± 5.8). Overall 30-day adverse events were equivalent among the four groups. Fusion to the pelvis was most common in the moderate sagittal (89.4%) and severe sagittal (97.5%) clusters. The severe coronal cluster had more osteotomies per case (median 11, IQR 6.5-14) and a higher rate of 30-day implant-related complications (5.5%). The severe sagittal and hyper-TK clusters had more three-column osteotomies (43% and 32.3%, respectively). Hyper-TK patients had shorter hospital stays. CONCLUSIONS This cohort of patients with complex ASD surgeries contained four natural clusters of deformity, each with distinct perioperative outcomes.
KW - adult spine deformity
KW - artificial intelligence
KW - cluster analysis
KW - multicenter database
KW - perioperative outcomes
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U2 - 10.3171/2023.1.SPINE221095
DO - 10.3171/2023.1.SPINE221095
M3 - Article
C2 - 36806173
AN - SCOPUS:85158894813
SN - 1547-5654
VL - 38
SP - 547
EP - 557
JO - Journal of Neurosurgery: Spine
JF - Journal of Neurosurgery: Spine
IS - 5
ER -