Calcium is necessary in the cell response to EM fields

Rouzan Karabakhtsian; Natasha Broude; Natalia Shalts; Serguei Kochlatyia; Reba Goodman; Ann S. Henderson

doi:10.1016/0014-5793(94)00618-0

Calcium is necessary in the cell response to EM fields

Rouzan Karabakhtsian, Natasha Broude, Natalia Shalts, Serguei Kochlatyia, Reba Goodman, Ann S. Henderson

Research output: Contribution to journal › Article › peer-review

92 Scopus citations

Abstract

Previous research showed that exposure of human HL-60 cells to extremely low frequency electromagnetic fields increases the steady-state levels of some mRNAs. Modifications in calcium flux have been suggested as a means of amplifying electromagnetic signals, and induced changes in calcium influx could hypothetically lead to gene activation. The present experiments tested the role of calcium in the response of cells to electromagnetic fields. Steady state transcript levels for c-fos and c-myc were determined under conditions of low extracellular calcium. The present study confirms that calcium plays a role in the response of cells to electromagnetic fields.

Original language	English (US)
Pages (from-to)	1-6
Number of pages	6
Journal	FEBS Letters
Volume	349
Issue number	1
DOIs	https://doi.org/10.1016/0014-5793(94)00618-0
State	Published - Jul 25 1994
Externally published	Yes

Keywords

Calcium
Extremely low frequency (elf) electromagnetic (EM) fields
RNA transcript

ASJC Scopus subject areas

Biophysics
Structural Biology
Biochemistry
Molecular Biology
Genetics
Cell Biology

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10.1016/0014-5793(94)00618-0

Cite this

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AU - Broude, Natasha

AU - Shalts, Natalia

AU - Kochlatyia, Serguei

AU - Goodman, Reba

AU - Henderson, Ann S.

PY - 1994/7/25

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AB - Previous research showed that exposure of human HL-60 cells to extremely low frequency electromagnetic fields increases the steady-state levels of some mRNAs. Modifications in calcium flux have been suggested as a means of amplifying electromagnetic signals, and induced changes in calcium influx could hypothetically lead to gene activation. The present experiments tested the role of calcium in the response of cells to electromagnetic fields. Steady state transcript levels for c-fos and c-myc were determined under conditions of low extracellular calcium. The present study confirms that calcium plays a role in the response of cells to electromagnetic fields.

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KW - RNA transcript

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Calcium is necessary in the cell response to EM fields

Abstract

Keywords

ASJC Scopus subject areas

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