C5b-9 and MASP2 deposition in skin and bone marrow microvasculature characterize hematopoietic stem cell transplant-associated thrombotic microangiopathy

Sonia Elhadad; Amy Chadburn; Cynthia Magro; Koen Van Besien; Elisha D.O. Roberson; John P. Atkinson; Hunter Terry; June Greenberg; Whitney Reid; John Chapin; Dennis Copertino; Sahar Geramfard; Lizamarie Bachier Rodriguez; Nina Orfali; Usama Gerghis; Tsiporah Shore; Sebastian Mayer; Jasimuddin Ahamed; Jeffrey Laurence

doi:10.1038/s41409-022-01723-5

C5b-9 and MASP2 deposition in skin and bone marrow microvasculature characterize hematopoietic stem cell transplant-associated thrombotic microangiopathy

Sonia Elhadad, Amy Chadburn, Cynthia Magro, Koen Van Besien, Elisha D.O. Roberson, John P. Atkinson, Hunter Terry, June Greenberg, Whitney Reid, John Chapin, Dennis Copertino, Sahar Geramfard, Lizamarie Bachier Rodriguez, Nina Orfali, Usama Gerghis, Tsiporah Shore, Sebastian Mayer, Jasimuddin Ahamed, Jeffrey Laurence

Medicine

Research output: Contribution to journal › Letter › peer-review

9 Scopus citations

Original language	English (US)
Pages (from-to)	1445-1447
Number of pages	3
Journal	Bone Marrow Transplantation
Volume	57
Issue number	9
DOIs	https://doi.org/10.1038/s41409-022-01723-5
State	Published - Sep 2022

ASJC Scopus subject areas

Hematology
Transplantation

Access to Document

10.1038/s41409-022-01723-5

Cite this

Elhadad, S., Chadburn, A., Magro, C., Van Besien, K., Roberson, E. D. O., Atkinson, J. P., Terry, H., Greenberg, J., Reid, W., Chapin, J., Copertino, D., Geramfard, S., Rodriguez, L. B., Orfali, N., Gerghis, U., Shore, T., Mayer, S., Ahamed, J., & Laurence, J. (2022). C5b-9 and MASP2 deposition in skin and bone marrow microvasculature characterize hematopoietic stem cell transplant-associated thrombotic microangiopathy. Bone Marrow Transplantation, 57(9), 1445-1447. https://doi.org/10.1038/s41409-022-01723-5

Elhadad, S, Chadburn, A, Magro, C, Van Besien, K, Roberson, EDO, Atkinson, JP, Terry, H, Greenberg, J, Reid, W, Chapin, J, Copertino, D, Geramfard, S, Rodriguez, LB, Orfali, N, Gerghis, U, Shore, T, Mayer, S, Ahamed, J & Laurence, J 2022, 'C5b-9 and MASP2 deposition in skin and bone marrow microvasculature characterize hematopoietic stem cell transplant-associated thrombotic microangiopathy', Bone Marrow Transplantation, vol. 57, no. 9, pp. 1445-1447. https://doi.org/10.1038/s41409-022-01723-5

@article{78c0dc91204f41fb93b5c427ab34bf7a,

title = "C5b-9 and MASP2 deposition in skin and bone marrow microvasculature characterize hematopoietic stem cell transplant-associated thrombotic microangiopathy",

author = "Sonia Elhadad and Amy Chadburn and Cynthia Magro and {Van Besien}, Koen and Roberson, {Elisha D.O.} and Atkinson, {John P.} and Hunter Terry and June Greenberg and Whitney Reid and John Chapin and Dennis Copertino and Sahar Geramfard and Rodriguez, {Lizamarie Bachier} and Nina Orfali and Usama Gerghis and Tsiporah Shore and Sebastian Mayer and Jasimuddin Ahamed and Jeffrey Laurence",

note = "Funding Information: We thank Daniel Greenberg, Sharon Barouk-Fox, Paula Bertram, Beatriz Lorenzo, Levi Y. Elhadad, and Yuzhou Zhang in the laboratory of Dr. Richard Smith of the University of Iowa for expert technical work. This work was supported by funds from: Omeros (JL), Jazz Pharmaceuticals (JL), and the NIH (RO1 HL148123 and HL123605 (JA), and R01 GM099111 (JPA.) and U54 HL112303 (JPA and EDOR)). Funding Information: We thank Daniel Greenberg, Sharon Barouk-Fox, Paula Bertram, Beatriz Lorenzo, Levi Y. Elhadad, and Yuzhou Zhang in the laboratory of Dr. Richard Smith of the University of Iowa for expert technical work. This work was supported by funds from: Omeros (JL), Jazz Pharmaceuticals (JL), and the NIH (RO1 HL148123 and HL123605 (JA), and R01 GM099111 (JPA.) and U54 HL112303 (JPA and EDOR)). Funding Information: JL has received a research grant and JL and UG have received speaker fees from Alexion. JL and SM have current research grants from Omeros, Inc., and JL from Jazz Pharmaceuticals. These entities did not have input in the study design, analysis, manuscript preparation, or decision to submit for publication. The remaining authors declare no competing financial interests. ",

year = "2022",

month = sep,

doi = "10.1038/s41409-022-01723-5",

language = "English (US)",

volume = "57",

pages = "1445--1447",

journal = "Bone Marrow Transplantation",

issn = "0268-3369",

publisher = "Nature Publishing Group",

number = "9",

}

TY - JOUR

T1 - C5b-9 and MASP2 deposition in skin and bone marrow microvasculature characterize hematopoietic stem cell transplant-associated thrombotic microangiopathy

AU - Elhadad, Sonia

AU - Chadburn, Amy

AU - Magro, Cynthia

AU - Van Besien, Koen

AU - Roberson, Elisha D.O.

AU - Atkinson, John P.

AU - Terry, Hunter

AU - Greenberg, June

AU - Reid, Whitney

AU - Chapin, John

AU - Copertino, Dennis

AU - Geramfard, Sahar

AU - Rodriguez, Lizamarie Bachier

AU - Orfali, Nina

AU - Gerghis, Usama

AU - Shore, Tsiporah

AU - Mayer, Sebastian

AU - Ahamed, Jasimuddin

AU - Laurence, Jeffrey

N1 - Funding Information: We thank Daniel Greenberg, Sharon Barouk-Fox, Paula Bertram, Beatriz Lorenzo, Levi Y. Elhadad, and Yuzhou Zhang in the laboratory of Dr. Richard Smith of the University of Iowa for expert technical work. This work was supported by funds from: Omeros (JL), Jazz Pharmaceuticals (JL), and the NIH (RO1 HL148123 and HL123605 (JA), and R01 GM099111 (JPA.) and U54 HL112303 (JPA and EDOR)). Funding Information: We thank Daniel Greenberg, Sharon Barouk-Fox, Paula Bertram, Beatriz Lorenzo, Levi Y. Elhadad, and Yuzhou Zhang in the laboratory of Dr. Richard Smith of the University of Iowa for expert technical work. This work was supported by funds from: Omeros (JL), Jazz Pharmaceuticals (JL), and the NIH (RO1 HL148123 and HL123605 (JA), and R01 GM099111 (JPA.) and U54 HL112303 (JPA and EDOR)). Funding Information: JL has received a research grant and JL and UG have received speaker fees from Alexion. JL and SM have current research grants from Omeros, Inc., and JL from Jazz Pharmaceuticals. These entities did not have input in the study design, analysis, manuscript preparation, or decision to submit for publication. The remaining authors declare no competing financial interests.

PY - 2022/9

Y1 - 2022/9

UR - http://www.scopus.com/inward/record.url?scp=85131602384&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85131602384&partnerID=8YFLogxK

U2 - 10.1038/s41409-022-01723-5

DO - 10.1038/s41409-022-01723-5

M3 - Letter

C2 - 35661836

AN - SCOPUS:85131602384

SN - 0268-3369

VL - 57

SP - 1445

EP - 1447

JO - Bone Marrow Transplantation

JF - Bone Marrow Transplantation

IS - 9

ER -

C5b-9 and MASP2 deposition in skin and bone marrow microvasculature characterize hematopoietic stem cell transplant-associated thrombotic microangiopathy

ASJC Scopus subject areas

Access to Document

Other files and links

Cite this