Abstract
The receptor for advanced glycation end products (RAGE), a multi-ligand receptor, is mostly associated with promoting inflammation and oxidative stress. In addition to advanced glycation end products (AGEs), its ligands include High mobility group box 1 protein (HMGB-1), S-100 proteins and beta-sheet fibrils. The effects of several metals and metalloids on RAGE expression and activation have been recently studied: in vivo and in vitro exposure to methylmercury, selenium, zinc, manganese, and arsenic was associated with a variety of RAGE-related alterations and behavioral impairments, which are mostly dependent upon the administration procedure (local vs. systemic) and age during exposure. Recently, C. elegans has been proposed as a potential novel model for studying RAGE-related pathologies; preliminary data regarding such model and its potential contribution to the study of metal-induced RAGE-related pathologies are discussed.
| Original language | English (US) |
|---|---|
| Article number | 1407 |
| Journal | International journal of environmental research and public health |
| Volume | 15 |
| Issue number | 7 |
| DOIs | |
| State | Published - Jul 4 2018 |
Keywords
- Arsenic
- C Elegans
- Manganese
- Methylmercury
- Receptor for advanced glycation end products
- Selenium
- Zinc
ASJC Scopus subject areas
- Public Health, Environmental and Occupational Health
- Pollution
- Health, Toxicology and Mutagenesis
