TY - JOUR
T1 - BXD recombinant inbred strains participate in social preference, anxiety and depression behaviors along sex-differences in cytokines and tactile allodynia
AU - López-Granero, Caridad
AU - Antunes dos Santos, Alessandra
AU - Ferrer, Beatriz
AU - Culbreth, Megan
AU - Chakraborty, Sudipta
AU - Barrasa, Angel
AU - Gulinello, Maria
AU - Bowman, Aaron B.
AU - Aschner, Michael
N1 - Funding Information:
MA was supported in part by NIH grants from the National Institute of Environmental Health Sciences, R01 ES10563, R01 ES07331 and R01 ES020852. Additional support was obtained from NIHP30 HD071593.
Publisher Copyright:
© 2017 Elsevier Ltd
PY - 2017/6/1
Y1 - 2017/6/1
N2 - Depression and anxiety are the most common psychiatric disorders, representing a major public health concern. Dysregulation of oxidative and inflammatory systems may be associated with psychiatric disorders, such as depression and anxiety. Due to the need to find appropriate animal models to the understanding of such disorders, we queried whether 2 BXD recombinant inbred (RI) mice strains (BXD21/TyJ RI and BXD84/RwwJ RI mice) and C57BL/6 wild-type mice show differential performance in depression and anxiety related behaviors and biomarkers. Specifically, we assessed social preference, elevated plus maze, forced swim, and Von Frey tests at 3–4 months-of-age, as well as activation of cytokines and antioxidant mRNA levels in the cortex at 7 months-of-age. We report that (1) the BXD84/RwwJ RI strain exhibits anxiety disorder and social avoidance-like behavior (2) BXD21/TyJ RI strain shows a resistance to depression illness, and (3) sex-dependent cytokine profiles and allodynia with elevated inflammatory activity were inherent to male BXD21/TyJ RI mice. In conclusion, we provide novel data in favor of the use of BXD recombinant inbred mice to further understand anxiety and depression disorders.
AB - Depression and anxiety are the most common psychiatric disorders, representing a major public health concern. Dysregulation of oxidative and inflammatory systems may be associated with psychiatric disorders, such as depression and anxiety. Due to the need to find appropriate animal models to the understanding of such disorders, we queried whether 2 BXD recombinant inbred (RI) mice strains (BXD21/TyJ RI and BXD84/RwwJ RI mice) and C57BL/6 wild-type mice show differential performance in depression and anxiety related behaviors and biomarkers. Specifically, we assessed social preference, elevated plus maze, forced swim, and Von Frey tests at 3–4 months-of-age, as well as activation of cytokines and antioxidant mRNA levels in the cortex at 7 months-of-age. We report that (1) the BXD84/RwwJ RI strain exhibits anxiety disorder and social avoidance-like behavior (2) BXD21/TyJ RI strain shows a resistance to depression illness, and (3) sex-dependent cytokine profiles and allodynia with elevated inflammatory activity were inherent to male BXD21/TyJ RI mice. In conclusion, we provide novel data in favor of the use of BXD recombinant inbred mice to further understand anxiety and depression disorders.
KW - Anxiety
KW - BXD RI mice
KW - Cytokines
KW - Depression
KW - Inflammation
KW - Nrf2
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U2 - 10.1016/j.psyneuen.2017.03.006
DO - 10.1016/j.psyneuen.2017.03.006
M3 - Article
C2 - 28324704
AN - SCOPUS:85015356940
SN - 0306-4530
VL - 80
SP - 92
EP - 98
JO - Psychoneuroendocrinology
JF - Psychoneuroendocrinology
ER -
