@article{30d9c82a71324ea7b50236ac4bdffe60,
title = "Burden of prematurity-associated recurrent wheezing: caregiver missed work in the D-Wheeze trial",
abstract = "Objective: This study describes the burden of prematurity-associated wheezing in black infants with respect to caregiver missed work. Study design: We analyzed data from the D-Wheeze trial (ClinicalTrials.gov identifier NCT01601847). Black infants between 28–0/7 to 36–6/7 weeks{\textquoteright} gestational age at birth receiving <28 days of supplemental oxygen were enrolled. The primary outcome was missed work to care for the infant in the first year. Results: 147/277 (53.1%) infants had caregivers who reported time off. In an adjusted model, vitamin D supplementation (OR 0.52 [95% CI 0.30–0.89]; P = 0.018), recurrent wheeze (OR 2.26 [95% CI, 1.15–4.44]; P = 0.018), and other children in the household <5 years old (OR 0.45 [95% CI 0.26–0.78]; P = 0.004) were significantly associated with caregiver missed work. Conclusions: Black premature infants had a significant burden of caregiver missed work, emphasizing the impact of prematurity-associated wheezing.",
author = "Lauren Ledingham and Curtis Tatsuoka and Nori Minich and Ross, {Kristie R.} and Kerns, {Leigh Ann} and Wagner, {Carol L.} and Mamta Fuloria and Sharon Groh-Wargo and Teresa Zimmerman and Hibbs, {Anna Maria}",
note = "Funding Information: Acknowledgements This research was supported by National Heart, Lung, and Blood Institute (NHLBI) and Office of Dietary Supplement of the National Institutes of Health (R01HL109293) and by the NHLBI (K24HL143291). We thank Rainbow Babies and Children{\textquoteright}s Hospital in Cleveland, OH for providing administrative and research assistance for this study. We thank the participants of the D-Wheeze trial for their contributions to the trial. Funding Information: Funding This study was funded by the NHLBI and ODS (R01HL109293) and by the 327 NHLBI (K24HL143291). Funding Information: Conflict of interest AMH and TZ reported receiving grants from the National Heart, Lung, and Blood Institute (NHLBI) and Office of Dietary Supplements (ODS). KRR reported receiving grants and/or nonfinancial support from the National Institutes of Health, ODS, Boehringer Ingelheim, Teva, GlaxoSmithKline, Merck, Flamel, and Jazz Pharmaceuticals, and Otsuka Pharma/Pharmavite. CLW reported receiving grants and/or personal fees from the National Institutes of Health/NHLBI and Church & Dwight Inc, for which she served as a scientific consultant. SG-W reported receiving speaker honoraria from Abbott Nutrition. CT reported receiving grants from the National Institutes of Health, ODS, National Science Foundation, and Biogen. MF reported receiving grants from the Eunice Kennedy Shriver National Institute of Child Health and Human Development (HD092533). LL and NM declare no potential conflict of interest. Publisher Copyright: {\textcopyright} 2020, The Author(s), under exclusive licence to Springer Nature America, Inc.",
year = "2021",
month = jan,
doi = "10.1038/s41372-020-0729-7",
language = "English (US)",
volume = "41",
pages = "69--76",
journal = "Journal of Perinatology",
issn = "0743-8346",
publisher = "Nature Publishing Group",
number = "1",
}