Brugada syndrome: Progress in genetics, risk stratification and management

Jorge Romero, Dan L. Li, Ricardo Avendano, Juan Carlos Diaz, Roderick Tung, Luigi Di Biase

Research output: Contribution to journalArticlepeer-review

5 Scopus citations


Brugada syndrome (BrS) is one of the most common causes of sudden cardiac death in normal structural heart individuals. First characterised in 1992, the global prevalence of BrS is unclear, with estimates placing it at around 0.05% and presenting most frequently in southeast Asian countries. This review aims to summarise the development in the understanding of BrS and, importantly, progress in its management, underpinned by knowledge regarding its genetics and molecular mechanisms. It also provides update on risk stratification and promising new therapies for BrS, including epicardial ablation. Future studies are required to increase understanding of the pathogenesis of this disease and to guide clinical practice.

Original languageEnglish (US)
Pages (from-to)19-27
Number of pages9
JournalArrhythmia and Electrophysiology Review
Issue number1
StatePublished - Mar 2019


  • Brugada syndrome
  • Epicardial ablation
  • Genetic testing
  • Radiofrequency ablation
  • Risk stratification

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Physiology (medical)


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