Brain metastasis in two patients with stage IA papillary serous carcinoma of the uterus

Deepa M. Narasimhulu, Neekianund Khulpateea, Keith Meritz, Yiquing Xu

Research output: Contribution to journalArticlepeer-review

1 Scopus citations


We report two cases of brain metastasis in patients initially diagnosed with extremely early stage UPSC after extensive staging surgery. They did not receive either adjuvant chemotherapy or adjuvant pelvic or vaginal cuff radiation. At the same time that these patients were diagnosed with systemic metastasis, they both had a local "drop" metastasis in the vulva or the vaginal cuff. After the initial response to palliative chemotherapy, they both developed brain metastasis. The pattern of recurrence with the lack of adjuvant treatment underscores the urgent need in further evaluation of the potential benefits of adjuvant treatment, including chemotherapy and possibly in combination with radiation in this highly aggressive disease.

Original languageEnglish (US)
Pages (from-to)1-4
Number of pages4
JournalGynecologic Oncology Reports
StatePublished - Aug 1 2015
Externally publishedYes


  • Adjuvant chemotherapy
  • Brain metastasis
  • Papillary serous carcinoma of the uterus
  • Pelvic radiation
  • Vaginal cuff radiation

ASJC Scopus subject areas

  • Oncology
  • Obstetrics and Gynecology


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