@article{c78948358f5a4fe9b61ceca93dd6c5d1,
title = "Brain glucose metabolism and its relation to amyloid load in middle-aged adults with childhood-onset epilepsy",
abstract = "Uncomplicated childhood-onset epilepsy is associated with increased brain amyloid load at late middle age, but its possible association with Alzheimer-type neurodegenerative processes is unclear. After 50-year follow-up, 42 childhood onset epilepsy subjects and 45 matched controls were investigated with [18F]fluorodeoxyglucose PET. There were no significant differences between the subjects and controls, but higher [18F]fluorodeoxyglucose uptake was associated with a higher local amyloid load (as measured with [11C]PIB PET) in the prefrontal cortex, parietal cortex, and posterior cingulate/precuneus in subjects but not in controls. These findings parallel reported observations in cognitively normal individuals with increased brain amyloid accumulation who are at risk for future Alzheimer's disease.",
keywords = "Aging, Alzheimer's, Epilepsy, Imaging, Positron emission tomography",
author = "{TACOE Study Group} and Juho Joutsa and Rinne, {Juha O.} and Mira Karrasch and Bruce Hermann and Jarkko Johansson and Anu Anttinen and Olli Eskola and Semi Helin and Shlomo Shinnar and Matti Sillanp{\"a}{\"a}",
note = "Funding Information: The study was funded by the Finnish Governmental Research Funding (EVO #13904/2010) and CURE Innovator award (B.H., M.S.). Funding Information: Dr Joutsa has received research grants from Lundbeck and Orion Research Foundation, and travel grants from Abbvie and Orion. Dr. Rinne reports grants from Sigrid Juselius Foundation, grants from Turku University Hospital, during the conduct of the study; and Dr. Rinne serves as a consultant for CRST Ltd (Clinical Research Services Turku). Dr. Karrasch serves as Associate Editor for Nordic Psychology. Dr. Hermann reports grants from Citizens United for Epilepsy Research (Co-PI), during the conduct of the study. Dr. Shinnar reports personal fees from Accorda, personal fees from AstraZenica, personal fees from Malinckrodt, personalfees from Neurelis, personal fees from Upsher-Smith, personal fees from UCB Pharma, and personal fees from Xeris outside the submitted work; In addition, Dr. Shinnar is Co-Editor of Book “Febrile Seizures” by Elsevier 2002 with royalties paid. Dr Anttinen, Dr Helin, Dr Eskola and Dr Sillanp{\"a}{\"a} have nothing to disclose. Publisher Copyright: {\textcopyright} 2017 Elsevier B.V.",
year = "2017",
month = nov,
doi = "10.1016/j.eplepsyres.2017.09.006",
language = "English (US)",
volume = "137",
pages = "69--72",
journal = "Epilepsy Research",
issn = "0920-1211",
publisher = "Elsevier",
}